Method for pretreating ranitidine hydrochloride sample

Abstract

Disclosed is a method for pretreating Ranitidine hydrochloride sample, comprising steps: S1, weighing the Ranitidine hydrochloride sample containing an impurity of N-nitrosodimethylamine; S2, preparing a test solution of Ranitidine hydrochloride so that the concentration of N-nitrosodimethylamine in the test solution reaches the detection limit of high-performance liquid chromatography; S3, adding an alkaline solution to the Ranitidine hydrochloride test solution, wherein the alkaline solution reacts completely with hydrochloric acid in Ranitidine hydrochloride to give a Ranitidine neutralizing solution; S4, adding a silver ion solution to the Ranitidine neutralizing solution, and silver ions undergo a complete complexation reaction with secondary amino groups in Ranitidine to generate a precipitate. The precipitation of Ranitidine in the high-concentration Ranitidine test article is removed without producing NDMA as a by-product while retaining NDMA in the sample, greatly improving the sensitivity of NDMA detection and meeting the detection requirements of various types of mass spectrometry.

Dependencies are inferred from the claim text.