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US 12,600,987 B2Granted
Compositions and methods for circular RNA expression
AssigneeDuke University
InventorsAravind Asokan, Rita Meganck
Life of this patent
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Abstract
The present disclosure provides nucleic acid molecules encoding for at least two circular RNA (circRNAs), adeno-associated virus (AAV) particles including nucleic acid molecules encoding for at least two circRNAs, pharmaceutical compositions, and methods for delivering such to a subject.
Claims15
A nucleic acid molecule, comprising:
- a nucleic acid sequence, wherein the nucleic acid sequence comprises a first circRNA-encoding sequence and a second circRNA-encoding sequence,
- wherein the first circRNA-encoding sequence is flanked by a left backsplicing intronic element and a right backsplicing intronic element;
- and
- wherein the second circRNA-encoding sequence is flanked by a left tRNA splicing element and a right tRNA splicing element.
1 more element
Dependencies are inferred from the claim text.