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US 12,600,959 B2Granted
PH20 polypeptide variants, formulations and uses thereof
AssigneeHalozyme, Inc.
InventorsGe Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
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Abstract
Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
Claims15
A modified PH20 polypeptide comprising the amino acid sequence of amino acids 38-340 of SEQ ID NO:
- 6, wherein the amino acid sequence has a first amino acid substitution at a residue corresponding to position 341 of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.