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US 12,600,949 B2Granted
Modified macrophages, compositions and uses thereof
AssigneeDuogenic Stemcells Corporation
InventorsHong-Lin Su, Ching-I Shen, Fu-Hui Wang, Chia-Ying Hsieh, Masataka Kiyokawa
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Abstract
The present invention provides modified monocytes, modified macrophages, pharmaceutical compositions comprising the modified monocytes or modified macrophages described herein and at least one pharmaceutically acceptable carrier or excipient. Uses of the modified monocytes or the modified macrophages for the treatment of musculoskeletal diseases and inducing cartilage formation are provided. Also disclosed herein are in vitro culture methods for generating the modified macrophages.
Claims17
A macrophage, comprising
- a macrophage phenotype CD14+CD206+;
- and
- type II collagen expression.
A monocyte, comprising
- a monocyte phenotype CD14+;
- and
- type II collagen expression.
Dependencies are inferred from the claim text.