Back to results
US 12,600,797 B2Granted
Fibrin-binding antibody and pharmaceutical composition containing antibody
AssigneesRin Institute Inc., National Cancer Center
InventorsYasuhiro Matsumura, Shingo Hanaoka, Shinji Saijo
Life of this patent
Estimating the term…
Abstract
The present invention provides an antibody that binds to fibrin and a pharmaceutical composition containing the antibody. According to the present invention, there is particularly provided a humanized antibody that binds to fibrin and a pharmaceutical composition containing the antibody.
Claims7
An antibody that binds to insoluble fibrin or an antigen-binding fragment thereof, comprising
- (1) a heavy chain variable region comprising heavy chain CDR1 having an amino acid sequence set forth in SEQ ID NO:1, heavy chain CDR2 having an amino acid sequence set forth in SEQ ID NO:2 and heavy chain CDR3 having an amino acid sequence set forth in SEQ ID NO:3, and
- a light chain variable region comprising light chain CDR1 having an amino acid sequence set forth in SEQ ID NO:4, light chain CDR2 having an amino acid sequence set forth in SEQ ID NO:5 and Light chain CDR3 having an amino acid sequence set forth in SEQ ID NO:6;
- or
- (2) a heavy chain variable region comprising heavy chain CDR1 having an amino acid sequence set forth in SEQ ID NO:9, heavy chain CDR2 having an amino acid sequence set forth in SEQ ID NO:10 and heavy chain CDR3 having an amino acid sequence set forth in SEQ ID NO:11, and
- a light chain variable region comprising light chain CDR1 having an amino acid sequence set forth in SEQ ID NO:12, light chain CDR2 having an amino acid sequence set forth in SEQ ID NO:13 and light chain CDR3 having an amino acid sequence set forth in SEQ ID NO:14.
2 more elements
Dependencies are inferred from the claim text.