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US 12,600,796 B2Granted
Constructs for chimeric antigen receptors
AssigneeCarisma Therapeutics Inc.
InventorsMichael Klichinsky, Nicholas G. Minutolo, Nicholas R. Anderson
Life of this patent
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Abstract
The present disclosure pertains to immune cells comprising chimeric antigen receptors (CARs) and methods of using immune cells comprising CARs.
Claims22
A macrophage or monocyte comprising a chimeric antigen receptor (CAR) comprising:
- (a) an extracellular domain,
- (b) a CD28 derived extracellular hinge domain,
- (c) a CD28 transmembrane domain, and
- (d) an intracellular domain,
- wherein the macrophage or monocyte exhibits increased tumor killing ability relative to a macrophage or monocyte comprising a similar CAR comprising a CD8 hinge domain.
2 more elements
A method of modifying a macrophage or monocyte, comprising delivering a nucleic acid construct comprising one or more nucleic acid sequences encoding a chimeric antigen receptor (CAR) comprising:
- (a) an extracellular domain,
- (b) a CD28 extracellular hinge domain,
- (c) a CD28 transmembrane domain, and
- (d) an intracellular domain,
- to the macrophage or monocyte, thereby producing a modified macrophage or monocyte that exhibits increased tumor killing ability relative to a macrophage or monocyte comprising a similar CAR comprising a CD8 hinge domain.
2 more elements
Dependencies are inferred from the claim text.