Modified S2 subunit of the coronavirus spike protein
OwnerAnnika Kraemer-Kuehl, Thomas Min Stephaninventors
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Abstract
A recombinant avian coronavirus spike protein or fragment thereof includes a mutation at amino acid position 865. An immunogenic composition includes an avian coronavirus with such spike protein.
Claims22
An avian coronavirus spike protein comprising an aromatic amino acid at position 865, wherein the spike protein provides extended cell or tissue tropism without requiring a change to the Beaudette specific motif, wherein the spike protein is not from infectious bronchitis virus (IBV) strain M41, and wherein the amino acid sequence of SEQ ID NO:1 is used for determining the position numbering in the spike protein.
An avian coronavirus spike protein, wherein at least a part of the S2 subunit is from an avian coronavirus with a restricted cell or tissue tropism, wherein the amino acid at position 865 is an aromatic amino acid, wherein the spike protein provides extended cell or tissue tropism without requiring a change to the Beaudette specific motif, and wherein the amino acid sequence of SEQ ID NO:1 is used for determining the position numbering in the spike protein.
Dependencies are inferred from the claim text.