Quinolinone derivative compound selectively binding to cysteine, peptide conjugate thereof, and antibody-drug conjugate comprising same

An amino acid- or peptide conjugate represented by the following Chemical Formula 2:

• wherein
• is a single amino acid, oligopeptide, polypeptide, or protein including cysteine residue;
• R1 to R5 are independently of one another hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C3-C20 heterocycloalkyl, C1-C20 alkoxy, C6-C20 aryl, or C3-C20 heteroaryl;
• R6 and R7 are independently of each other hydrogen, C1-C20 alkyl, C1-C20 alkoxy, C6-C20 aryl, or C3-C20 heterocycloalkyl;
• L1 is C4-C20 alkylene or C1-C20 oxyalkylene;
• X is hydrogen, halogen, C1-C10 alkyl, C1-C7 haloalkyl, C1-C10 alkoxy, C1-C10 haloalkoxyl, or C6-C20 aryl;
• the heteroaryl and the heterocycloalkyl independently of each other contain one or more heteroatoms selected from nitrogen, oxygen, and sulfur;
• alkyl, cycloalkyl, heterocycloalkyl, alkoxy, aryl, and heteroaryl of R1 to R5 may be further substituted by any one or more selected from the group consisting of —OR′, —COR′, —NR′R″, —NR′COR″, —NHCOR′, —NHCOCH2NR′R″, and —NR′PO(OR″)(OH);
• and
• R′ and R″ are independently of each other any one selected from the group consisting of hydrogen, C1-C7 alkyl, C3-C6 cycloalkyl, C3-C6 alkenyl, and C3-C6 alkynyl.

An amino acid- or peptide conjugate represented by the following Chemical Formula 3 or Chemical Formula 4:

• wherein
• R1 to R5 are independently of one another hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C3-C20 heterocycloalkyl, C1-C20 alkoxy, C6-C20 aryl, or C3-C20 heteroaryl;
• R6 and R7 are independently of each other hydrogen, C1-C20 alkyl, C1-C20 alkoxy, C6-C20 aryl, or C3-C20 heterocycloalkyl;
• L2, L3, and R are C1-C5 alkylene,
• L2, L3, and R may be further substituted by one or more selected from halogen, C1-C10 alkyl, C1-C10 alkoxy, C1-C10 haloalkoxyl, C6-C20 aryl, and combinations thereof,
• in Chemical Formula 3, R2a and R2b are independently of each other hydrogen or an acetyl group,
• in Chemical Formula 4, R3a and R3b are identical or different side chains of amino acid, and
• n is an integer of 0 to 10, and 1 and m are integers of 0 to 400.