# US 12,600,732 B2 · Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,600,732 B2 - Document ID: US12600732B2 - Status: Granted - Kind: B2 - Application number: 18/120,341 - Filed: 2023-03-10 - Published: 2023-07-20 - Granted: 2026-04-14 - Earliest claimed: 2019-12-04 - Assignees: Nurix Therapeutics, Inc. - Applicants: Nurix Therapeutics, Inc. - Inventors: Aileen Kelly; Arthur T. Sands - Web page: https://patentgrep.com/patent/US12600732B2 ## CPC - A61K 31/497: containing further heterocyclic rings - C07D 498/10: Spiro-condensed systems - A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol - A61P 35/00: Antineoplastic agents - A61P 37/00: Drugs for immunological or allergic disorders - C07D 401/14: containing three or more hetero rings - C07D 413/14: containing three or more hetero rings - C07D 417/14: containing three or more hetero rings - C07D 471/04: Ortho-condensed systems - C07D 471/10: Spiro-condensed systems - C07D 487/04: Ortho-condensed systems - C07D 487/10: Spiro-condensed systems - C07D 491/107: with only one oxygen atom as ring hetero atom in the oxygen-containing ring - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract This disclosure relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The description also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. ## Claims ### Claim 1 A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. ### Claim 2 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 3 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 4 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 5 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 6 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 7 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 8 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 9 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 10 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 11 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 12 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 13 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 14 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 15 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 16 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 17 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 18 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 19 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 20 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 21 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 22 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 23 (depends on 1) The compound of claim 1, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 24 (depends on 1) A pharmaceutical composition comprising the compound according to claim 1 or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, vehicle, or adjuvant. ### Claim 25 A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. ### Claim 26 (depends on 25) The compound of claim 25, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 27 (depends on 25) The compound of claim 25, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 28 (depends on 25) A pharmaceutical composition comprising the compound according to claim 25 or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, vehicle, or adjuvant. ### Claim 29 A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. ### Claim 30 (depends on 29) The compound of claim 29, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 31 (depends on 29) The compound of claim 29, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 32 (depends on 29) The compound of claim 29, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 33 (depends on 29) The compound of claim 29, wherein the compound is or pharmaceutically acceptable salt thereof. ### Claim 34 (depends on 29) A pharmaceutical composition comprising the compound according to claim 29 or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, vehicle, or adjuvant. ### Claim 35 A compound or a pharmaceutically acceptable salt thereof, wherein the compound is: ### Claim 36 (depends on 35) A pharmaceutical composition comprising the compound according to claim 35 or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, vehicle, or adjuvant.