Treatment of infections of toxoplasma gondii and closely related parasites
AssigneesWashington University, The Broad Institute, Inc., President and Fellows of Harvard College
InventorsL. David Sibley, Joshua Radke, Eamon Comer, Marshall Morningstar, Bruno Melillo
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease.
Claims18
A method of treatment or prophylaxis of Toxoplasma gondii infection, Sarcocystis neurona infection, or Neospora caninum infection in a subject in need thereof comprising administering to said subject a compound having the structure of formula (I):
- wherein the dashed bond (- - -) may be a single or double bond;
- m is 0 (i.e., it is a bond) or 1;
- n is 0, 1 or 2;
- A is CH or N;
- L1 is absent (i.e., it is a bond), or —C≡C—;
- L2 is absent, alkylene, —C(O)NR—;
- —SO2—, or —C(O)—;
- L3 is absent, alkylene, or heteroalkylene;
- R1 is hydrogen, heteroalkyl, aryl, heteroaryl, or cycloalkyl, and R1 is optionally substituted;
- R2 is perfluoroalkyl, aryl, arylalkyl, alkyl, heteroaryl, or cycloalkyl, and R2 is optionally substituted;
- R3 is —N(R)S(O)2R;
- R4 is hydrogen or —CH2OH;
- R5 and R6 are independently selected from hydrogen and OH;
- and
- R is independently selected at each occurrence from hydrogen and lower alkyl, wherein R is optionally substituted.
A compound having the structure of formula (IV):
- wherein R1 is aryl, heteroaryl, or cycloalkyl optionally substituted with —CN;
- R2 is aryl, heteroaryl, or cycloalkyl optionally substituted with halogen or —OR;
- R3 is —N(R)S(O)2R;
- R4 is hydrogen or —CH2OH;
- and
- R is independently selected at each occurrence from alkyl or cycloalkyl optionally substituted with halogen, or —OH.
Dependencies are inferred from the claim text.