Back to results
US 12,600,708 B2Granted
Prodrug compounds of 3,4-methylenedioxymethamphetamine (MDMA) and methods of synthesizing the same
AssigneeApoapsis Holdings, LLC
InventorsDenton W. Hoyer, Robert F. Roscow, Rong Ling, Chuanjun Gao
Life of this patent
Estimating the term…
Abstract
The present invention includes a novel class of MDMA carbamates that can be activated in vivo as prodrugs. The MDMA prodrugs of the invention are enzymatically cleaved in vivo and produce alcohols of low toxicity that are well tolerated and metabolized in humans.
Claims19
A prodrug compound according to Formula I:
- or pharmaceutically acceptable salt thereof, wherein,
- X1 is O or S, and when X1 is O then X2 is S;
- X2 is O or S, and when X2 is O, then X1 is S;
- A is O;
- R1 is a C5-C18 alkyl.
2 more elements
A compound selected from:
- or pharmaceutically acceptable salt thereof.
A compound selected from:
A compound selected from:
Dependencies are inferred from the claim text.