# US 12,599,787 B2 · All-in-one ultrasound systems and methods including histotripsy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,599,787 B2 - Document ID: US12599787B2 - Status: Granted - Kind: B2 - Application number: 18/568,045 - Filed: 2022-04-07 - Published: 2024-08-15 - Granted: 2026-04-14 - Earliest claimed: 2021-06-07 - Assignees: The Regents of the University of Michigan - Applicants: The Regents of the University of Michigan - Inventors: Zhen Xu; Jonathan Robert Sukovich; Timothy Lewis Hall - Web page: https://patentgrep.com/patent/US12599787B2 ## CPC - A61N 7/02: Localised ultrasound hyperthermia - A61B 8/4488: {the transducer being a phased array} - A61B 8/483: {involving the acquisition of a 3D volume of data} - A61B 8/5261: {combining images from different diagnostic modalities, e.g. ultrasound and X-ray} - A61N 2007/0026: {Stimulation of nerve tissue} - A61N 2007/0039: {using microbubbles} - A61N 2007/0073: {using multiple frequencies} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract An all-in-one ultrasound therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious ultrasound therapy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures. The ultrasound therapy can include modalities such as histotripsy, hyperthermia/radio-sensitization, HIFU microbubble-enhanced drug delivery, immunotherapy, sonodynamic therapy, and/or neuromodulation. ## Claims ### Claim 1 An ultrasound system driving architecture configured to drive an ultrasound transducer array with a plurality of ultrasound modalities, the ultrasound system driving architecture comprising: a power supply switching circuit configured to switch between a first power mode that provides a first voltage and a first current and a second power mode that provides a second voltage and a second current, wherein the second voltage is higher than the first voltage and the second current is lower than the first current; and a current driver circuit comprising a gate driver configured to receive a digital drive signal, a transformer electrically coupled to the ultrasound transducer array, a transistor electrically coupled to the gate driver and the transformer, and a first resistor and a first capacitor electrically coupled to the transistor and configured to slow down a turn-on time and a turn-off time of the transistor to reduce RF noise emissions, wherein the gate driver is configured to drive the transistor at a first pulse repetition frequency when the power supply switching circuit is operating in the first power mode to produce ultrasound pulses of a first ultrasound therapy modality, and wherein the gate driver is configured to drive the transistor at a second pulse repetition frequency when the power supply switching circuit is operating in the second power mode to produce ultrasound pulses of a second ultrasound therapy modality. ### Claim 2 (depends on 1) The ultrasound driving system architecture of claim 1, wherein the first ultrasound therapy modality is selected from the group consisting of hyperthermia/radio-sensitization, HIFU, microbubble-enhanced drug delivery, immunotherapy, sonodynamic therapy, and neuromodulation. ### Claim 3 (depends on 1) The ultrasound driving system architecture of claim 1, wherein the second ultrasound therapy modality comprises histotripsy. ### Claim 4 (depends on 1) The ultrasound driving system architecture of claim 1, further comprising a blocking diode electrically connected to the transistor and configured to prevent the transistor from conducting when a polarity of the transistor is negative. ### Claim 5 (depends on 1) The ultrasound driving system architecture of claim 1, wherein a secondary winding of the transformer is configured to resonate with a capacitance of the ultrasound transducer array. ### Claim 6 (depends on 1) The ultrasound driving system architecture of claim 1, wherein the power supply switching circuit further comprises: a first transistor configured to connect the power supply switching circuit to a first power supply; and a second transistor configured to connect the power supply switching circuit to a second power supply. ### Claim 7 (depends on 1) The ultrasound driving system architecture of claim 1, wherein the current driver circuit is further configured to enable the ultrasound transducer array to measure ultrasound signals. ### Claim 8 (depends on 7) The ultrasound driving system architecture of claim 7, wherein the current driver circuit further comprises a current sensing resistor and a digitizer configured to measure a voltage across the current sensing resistor. ### Claim 9 (depends on 8) The ultrasound driving system architecture of claim 8, further comprising a pair of MOSFETs in parallel with the current sensing resistor configured to block transmit currents. ### Claim 10 (depends on 8) The ultrasound driving system architecture of claim 8, further comprising a second current sensing resistor configured to be switched into the current driver circuit in parallel with the current sensing resistor to reduce a gain in the circuit. ### Claim 11 An ultrasound system driving architecture configured to drive an ultrasound transducer array with a plurality of ultrasound modalities, the ultrasound system driving architecture comprising: a power supply switching circuit configured to switch between a first power mode that provides a first voltage and a first current and a second power mode that provides a second voltage and a second current, wherein the second voltage is higher than the first voltage and the second current is lower than the first current; and a current driver circuit comprising a gate driver configured to receive a digital drive signal, a transformer electrically coupled to the ultrasound transducer array, a transistor electrically coupled to the gate driver and the transformer, and a blocking diode electrically connected to the transistor and configured to prevent the transistor from conducting when a polarity of the transistor is negative, wherein the gate driver is configured to drive the transistor at a first pulse repetition frequency when the power supply switching circuit is operating in the first power mode to produce ultrasound pulses of a first ultrasound therapy modality, and wherein the gate driver is configured to drive the transistor at a second pulse repetition frequency when the power supply switching circuit is operating in the second power mode to produce ultrasound pulses of a second ultrasound therapy modality. ### Claim 12 (depends on 11) The ultrasound driving system architecture of claim 11, wherein the first ultrasound therapy modality is selected from the group consisting of hyperthermia/radio-sensitization, HIFU, microbubble-enhanced drug delivery, immunotherapy, sonodynamic therapy, and neuromodulation. ### Claim 13 (depends on 11) The ultrasound driving system architecture of claim 11, wherein the second ultrasound therapy modality comprises histotripsy. ### Claim 14 (depends on 11) The ultrasound driving system architecture of claim 11, wherein a secondary winding of the transformer is configured to resonate with a capacitance of the ultrasound transducer array. ### Claim 15 (depends on 11) The ultrasound driving system architecture of claim 11, wherein the power supply switching circuit further comprises: a first transistor configured to connect the power supply switching circuit to a first power supply; and a second transistor configured to connect the power supply switching circuit to a second power supply. ### Claim 16 (depends on 11) The ultrasound driving system architecture of claim 11, wherein the current driver circuit is further configured to enable the ultrasound transducer array to measure ultrasound signals. ### Claim 17 (depends on 16) The ultrasound driving system architecture of claim 16, wherein the current driver circuit further comprises a current sensing resistor and a digitizer configured to measure a voltage across the current sensing resistor. ### Claim 18 (depends on 17) The ultrasound driving system architecture of claim 17, further comprising a pair of MOSFETs in parallel with the current sensing resistor configured to block transmit currents. ### Claim 19 (depends on 17) The ultrasound driving system architecture of claim 17, further comprising a second current sensing resistor configured to be switched into the current driver circuit in parallel with the current sensing resistor to reduce a gain in the circuit.