# US 12,599,772 B2 · Selection of sensing electrodes in a spinal cord stimulator system using sensed stimulation artifacts

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- Number: US 12,599,772 B2
- Document ID: US12599772B2
- Status: Granted
- Kind: B2
- Application number: 18/736,300
- Filed: 2024-06-06
- Published: 2024-09-26
- Granted: 2026-04-14
- Earliest claimed: 2020-02-05
- Assignees: Boston Scientific Neuromodulation Corporation
- Applicants: Boston Scientific Neuromodulation Corporation
- Inventors: Tianhe Zhang; Rosana Esteller; Thomas W. Stouffer
- Web page: https://patentgrep.com/patent/US12599772B2

## CPC

- A61N 1/36062: {Spinal stimulation}
- A61N 1/37235: {Aspects of the external programmer}
- A61B 5/1116: {Determining posture transitions}
- A61B 5/311: for nerve conduction study [NCS]
- A61B 5/388: Nerve conduction study, e.g. detecting action potential of peripheral nerves
- A61B 5/407: {Evaluating the spinal cord (for locating the epidural space A61B5/4896)}
- A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)}
- A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)}
- A61B 5/7217: {of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker}
- A61N 1/0551: {Spinal or peripheral nerve electrodes}
- A61N 1/36135: {using physiological parameters}
- A61N 1/36139: {with automatic adjustment}
- A61N 1/36185: {Selection of the electrode configuration}
- A61N 1/37241: {providing test stimulations}
- A61B 5/4833: {Assessment of subject's compliance to treatment}
- A61B 5/7235: {Details of waveform analysis (detecting specific parameters of the electrocardiograph cycle A61B5/349)}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A sensing electrode selection algorithm is disclosed for use with an implantable pulse generator having an electrode array. The algorithm automatically selects optimal sensing electrodes in the array to be used with a pre-determined stimulation therapy appropriate for the patient. The algorithm preferably senses stimulation artifacts using different sensing electrodes, and more specifically different sensing electrode pairs as is appropriate when differential sensing is used. The algorithm further preferably senses these stimulation artifacts with the patient placed in two or more postures. The algorithm processes the stimulation artifact features measured at the different sensing electrodes and at the different postures to automatically determine one or more sensing electrode pairs that best distinguishes the two or more postures given the prescribed stimulation therapy.

## Claims

### Claim 1

A method for programming a stimulator device, the stimulator device comprising a plurality of electrodes configured to contact a patient's tissue, the method comprising:
(a) determining stimulation to be applied at at least two of the electrodes;
(b) sensing a response to the stimulation at a plurality of combinations of the electrodes with the patient in different postures;
(c) for each of the plurality of combinations, determining at least one difference in the sensed response between two of the postures, and using the at least one difference at each of the plurality of combinations to determine one or more optimal of the combinations; and
(d) programming the stimulator device with the one or more optimal combinations to be used for sensing with the stimulation.

### Claim 2 (depends on 1)

The method of claim 1, wherein the sensed response comprises a stimulation artifact, wherein the stimulation artifact comprises a signal formed by an electric field induced in the tissue by the stimulation.

### Claim 3 (depends on 1)

The method of claim 1, wherein the sensed response comprises a neural response formed by recruitment of neural fibers in the tissue in response to the stimulation.

### Claim 4 (depends on 1)

The method of claim 1, wherein the plurality of combinations exclude the at least two electrodes to which the stimulation is to be applied.

### Claim 5 (depends on 1)

The method of claim 1, wherein steps (a), (c), and (d) are performed using an external device in communication with the stimulator device.

### Claim 6 (depends on 1)

The method of claim 1, wherein the method is performed within the stimulator device.

### Claim 7 (depends on 1)

The method of claim 1, wherein the sensed response is sensed differentially using both of the electrodes in each of the combinations.

### Claim 8 (depends on 1)

The method of claim 1, wherein there are two postures, and wherein for each of the plurality of combinations, a single difference in the sensed response is determined between the two postures, wherein the single difference at each of the plurality of combinations is used to determine the one or more optimal combinations.

### Claim 9 (depends on 8)

The method of claim 8, wherein the one or more optimal combinations are determined as one or more combinations having a largest of the single difference.

### Claim 10 (depends on 1)

The method of claim 1, wherein there are three or more postures.

### Claim 11 (depends on 10)

The method of claim 10, wherein for each of the combinations, a plurality of differences in the sensed response is determined between two of the three or more postures, wherein the plurality of differences at each of the plurality of combinations is used to determine the one or more optimal combinations.

### Claim 12 (depends on 11)

The method of claim 11, further comprising summing the plurality of differences for each of the plurality of combinations.

### Claim 13 (depends on 12)

The method of claim 12, further comprising multiplying the summed difference by a minimum of the addends to form a weighted value for each of the plurality of combinations, wherein the one or more optimal combinations are determined as the one or more combinations having the largest weighted value.

### Claim 14 (depends on 1)

The method of claim 1, wherein the stimulator device comprises a Spinal Cord Stimulator device.

### Claim 15 (depends on 1)

The method of claim 1, further comprising after step (d):
(e) sensing a response to the stimulation at the determined one or more optimal combinations; and
(f) determining a posture of the patient using the sensed response at step (e).

### Claim 16 (depends on 15)

The method of claim 15, further comprising:
(g) adjusting the stimulation in accordance with the determined posture.

### Claim 17

An external device for programming a stimulator device, the stimulator device comprising a plurality of electrodes configured to contact a patient's tissue, the external device comprising:
control circuitry configured to:
(a) determine stimulation to be applied at at least two of the electrodes;
(b) receive a response to the stimulation at a plurality of combinations of the electrodes with the patient in different postures;
(c) for each of the plurality of combinations, determine at least one difference in the sensed response between two of the postures, and use the at least one difference at each of the plurality of combinations to determine one or more optimal of the combinations; and
(d) program the stimulator device with the one or more optimal combinations to be used for sensing with the stimulation.

### Claim 18

A non-transitory computer readable media including instructions executable on an external device for programming a stimulator device, the stimulator device comprising a plurality of electrodes configured to contact a patient's tissue, wherein the instructions when executed are configured to:
(a) determine stimulation to be applied at at least two of the electrodes;
(b) receive a response to the stimulation at a plurality of combinations of the electrodes with the patient in different postures;
(c) for each of the plurality of combinations, determine at least one difference in the sensed response between two of the postures, and use the at least one difference at each of the plurality of combinations to determine one or more optimal of the combinations; and
(d) program the stimulator device with the one or more optimal combinations to be used for sensing with the stimulation.