# US 12,599,765 B2 · Shifting of transducer array to reduce skin irritation

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- Number: US 12,599,765 B2
- Document ID: US12599765B2
- Status: Granted
- Kind: B2
- Application number: 18/080,091
- Filed: 2022-12-13
- Published: 2023-06-15
- Granted: 2026-04-14
- Earliest claimed: 2021-12-14
- Assignees: Novocure GmbH
- Applicants: Novocure GmbH
- Inventors: Noa Halavee; Boaz Marsault; Elie Yaacobi; Golan Bar-Tal; Nitzan Shany
- Web page: https://patentgrep.com/patent/US12599765B2

## CPC

- A61N 1/06: for high-frequency therapy
- A61N 1/36002: {Cancer treatment, e.g. tumour}
- A61N 1/0408: {Use-related aspects}
- A61N 1/0476: {Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)}
- A61N 1/0492: {Patch electrodes (A61N1/0412, A61N1/0428 take precedence)}
- A61N 1/0472: {Structure-related aspects}
- A61N 1/0496: {characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives}
- A61N 1/40: Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals}
- A61N 1/403: {for thermotherapy, e.g. hyperthermia}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus including: an array of electrodes, the array configured to be positioned over the subject's body with a face of the array facing the subject's body, the array including electrode elements positioned in existing electrode positions arranged around a centroid of the array; and at least one void space in the array capable of enclosing an areal footprint equivalent to at least 40% of an areal footprint of at least one existing electrode position, and superimposable on at least 40% of at least one existing electrode position by rotation of the array around the centroid.

## Claims

### Claim 1

A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus comprising:
an array of electrodes, the array configured to be positioned over the subject's body with a face of the array facing the subject's body, the array comprising electrode elements positioned in existing electrode positions arranged around a centroid of the array; and
at least one void space in the array capable of enclosing an areal footprint equivalent to at least 40% of an areal footprint of at least one existing electrode position, and superimposable on at least 40% of at least one existing electrode position by rotation of the array around the centroid.

### Claim 2 (depends on 1)

The transducer apparatus of claim 1, wherein the at least one void space in the array is capable of enclosing an areal footprint equivalent to at least 95% of an areal footprint of at least one existing electrode position, and superimposable on at least 95% of at least one existing electrode position by rotation of the array around the centroid.

### Claim 3 (depends on 1)

The transducer apparatus of claim 1, wherein a sum total of the areal footprints for every void space in the array is approximately 50% of a sum total of the areal footprints for every void space and every existing electrode position of the array.

### Claim 4 (depends on 1)

The transducer apparatus of claim 1, wherein a sum total of the areal footprints for every void space in the array is equivalent to at least 20% of a sum total of the areal footprints for every void space and every existing electrode position of the array.

### Claim 5 (depends on 1)

The transducer apparatus of claim 1, wherein the array comprises:
a first group of electrode elements positioned in existing electrode positions arranged in a first circular region around the centroid; and
a second group of electrode elements different from the first group and positioned in existing electrode positions arranged in a second circular region concentric with the first circular region.

### Claim 6

A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus comprising:
an array of electrodes, the array configured to be positioned over the subject's body with a face of the array facing the subject's body, said array comprising electrode elements positioned in existing electrode positions arranged around a centroid of the array, and each tracing an existing electrode footprint;
the array also comprising one or more void spaces defining potential electrode positions, said potential electrode positions being arranged around the centroid of the array, each potential electrode position tracing a potential electrode footprint, wherein each potential electrode footprint has an identical shape, area, and distance from the centroid, as that of one or more existing electrode footprints, and in rotational coincidence about the centroid with said one or more existing electrode footprints, such that a rotational shift of the electrode array about the centroid may position at least one potential electrode position to be coincident upon an existing electrode position, thereby providing a resting state for an area of skin beneath at least one electrode after the rotation.

### Claim 7 (depends on 6)

The transducer apparatus of claim 6, wherein the total area occupied by potential electrode positions is no greater than 50% of the sum of the total areas of the potential electrode positions and existing electrode positions.

### Claim 8 (depends on 6)

The transducer apparatus of claim 6, wherein the array comprises one or more potential electrode positions in one or more void spaces such that the combined distribution of potential electrode positions and existing electrode positions exhibit Cx symmetry with respect to rotation about the centroid, where x is an integer, and wherein the potential electrode footprints are considered to be identical to the existing electrode footprints in determining the rotational symmetry of the combined potential electrode positions and existing electrode positions.

### Claim 9 (depends on 8)

The transducer apparatus of claim 8, wherein the Cx symmetry is C2 symmetry, C4 symmetry, C8 symmetry, C9 symmetry, C10 symmetry, or C12 symmetry.

### Claim 10 (depends on 8)

The transducer apparatus of claim 8, wherein the Cx symmetry is C8 symmetry, C10 symmetry, or C12 symmetry.

### Claim 11 (depends on 6)

The transducer apparatus of claim 6, wherein:
the rotational symmetry of the existing electrode positions with respect to rotation about the centroid is either Cx′, or no rotational symmetry;
the rotational symmetry of the combined distribution of potential electrode positions and existing electrode positions with respect to rotation about the centroid is Cx symmetry;
an unproductive rotation results in the same array pattern and the same areas of skin covered for the existing electrode positions, and a productive rotation results in at least one existing electrode position being exchanged for a potential electrode position;
wherein x and x′ are integers; and
wherein the productive rotations are given by rotations of 360/x and integer multiples thereof except for rotations of 360/x′ and integer multiples thereof;
optionally,
wherein x is equivalent to 2x′, 3x′, 4x′, or 5x′.

### Claim 12 (depends on 11)

The transducer apparatus of claim 11, wherein there are 6 existing electrode positions, and wherein the rotational symmetry of the existing electrode positions with respect to rotation about the centroid is C6 and the rotational symmetry of the combined distribution of potential electrode positions and existing electrode positions with respect to rotation about the centroid is C12 symmetry.

### Claim 13 (depends on 6)

The transducer apparatus of claim 6, wherein the existing electrode footprint of at least one electrode element of the array has a different shape than, and an identical distance from the centroid as, the potential electrode footprint of at least one potential electrode position.

### Claim 14 (depends on 6)

The transducer apparatus of claim 6, wherein the one or more void spaces define a first potential electrode position located a first distance from the centroid and a second potential electrode position located a second distance from the centroid, the first and second distances being different from each other.

### Claim 15 (depends on 6)

The transducer apparatus of claim 6, wherein the existing electrode footprint of at least one electrode element of the array has a different shape or a different size than the existing electrode footprint of at least one other electrode element of the array.

### Claim 16 (depends on 6)

The transducer apparatus of claim 6, wherein at least one single rotation about the centroid results in all potential electrode positions moving to be coincident with positions previously occupied by existing electrode positions, thereby providing a resting state for all areas of skin beneath all of the electrodes in existing electrode positions.

### Claim 17 (depends on 16)

The transducer apparatus of claim 16, wherein there are 6 existing electrode positions.

### Claim 18 (depends on 6)

The transducer apparatus of claim 6, wherein the array of electrodes has a non-circular shape.

### Claim 19 (depends on 6)

The transducer apparatus of claim 6, wherein each electrode element extends radially outward away from the centroid.

### Claim 20 (depends on 6)

The transducer apparatus of claim 6, wherein said array comprising electrode elements has 6 electrode elements positioned in existing electrode positions arranged around a centroid of the array, and each tracing an existing electrode footprint.