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US 12,599,706 B2Granted
Adhesion prevention with shear-thinning polymeric hydrogels
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsEric Andrew Appel, Y. Joseph Woo, Lyndsay Stapleton
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Abstract
A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.
Claims20
A method comprising:
- applying a supramolecular hydrogel to a tissue after a surgical procedure performed on or proximate to the tissue, the supramolecular hydrogel comprising a hydrophobically modified cellulose derivative non-covalently cross-linked with a plurality of nanoparticles;
- and
- inhibiting formation of an adhesion on the tissue with the applied supramolecular hydrogel.
A method comprising:
- administering a dynamically cross-linked hydrogel to a tissue after a surgical procedure performed on or proximate to the tissue to inhibit adhesion formation, the dynamically cross-linked hydrogel comprising non-covalent interactions between a hydrophobically modified cellulose derivative and a plurality of nanoparticles.
Dependencies are inferred from the claim text.