# US 12,599,702 B2 · Bone regeneration material

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- Number: US 12,599,702 B2
- Document ID: US12599702B2
- Status: Granted
- Kind: B2
- Application number: 17/274,893
- Filed: 2019-10-03
- Published: 2022-02-24
- Granted: 2026-04-14
- Earliest claimed: 2018-10-04
- Assignees: Nipro Corporation
- Applicants: Nipro Corporation
- Inventors: Osamu Suzuki; Yoshikatsu Sugahara; Satoshi Urai; Yusuke Nakamura
- Web page: https://patentgrep.com/patent/US12599702B2

## CPC

- A61L 27/46: with phosphorus-containing inorganic fillers
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A bone regeneration material according to the present disclosure includes at least a composite of octacalcium phosphate (OCP) particles and gelatin, and is a porous body having a plurality of pores. The particle size of the octacalcium phosphate particles is 1 μm or more but less than 1 mm, and the molecular weight of the gelatin is in the range of 30 kDa to 70 kDa. Thus, the material is able to resist breaking down during implantation and exhibit high handleability.

## Claims

### Claim 1

A bone regeneration material comprising at least a composite of octacalcium phosphate particles and gelatin, the bone regeneration material being a porous body configured to be soaked to a soaked state, the porous body having a plurality of pores, wherein
a particle size of the octacalcium phosphate particles is 1 μm or more but less than 1 mm,
an elastic modulus of the bone regeneration material in the soaked state is in a range of 0.01 N/mm2 to 0.0750 N/mm2, and
a molecular weight or a molecular weight distribution of the gelatin is in a range of 30 kDa to 70 kDa.

### Claim 2 (depends on 1)

The bone regeneration material according to claim 1, wherein
a porosity is in a range of 87% to 98%, the porosity being a volume ratio of the pores present in the porous body, and
a median size of the pores is in a range of 14 μm to 55 μm.

### Claim 3 (depends on 1)

The bone regeneration material according to claim 1, wherein the particle size of the octacalcium phosphate particles is in a range of 1 μm to 200 μm.

### Claim 4 (depends on 1)

The bone regeneration material according to claim 1, wherein a mass ratio of the octacalcium phosphate particles to the gelatin in the composite is in a range of 1 to 9.

### Claim 5 (depends on 1)

The bone regeneration material according to claim 1, wherein the bone regeneration material maintains a shape retaining property after being subjected to three repeated compressions in each of which the bone regeneration material is compressed to 75% of an original height of the bone regeneration material.

### Claim 6 (depends on 1)

The bone regeneration material according to claim 1, wherein the gelatin coats an entire periphery of each of the octacalcium phosphate particles.

### Claim 7 (depends on 6)

The bone regeneration material according to claim 6, wherein
a porosity is in a range of 87% to 98%, the porosity being a volume ratio of the pores present in the porous body, and
a median size of the pores is in a range of 14 μm to 55 μm.

### Claim 8 (depends on 6)

The bone regeneration material according to claim 6, wherein the particle size of the octacalcium phosphate particles is in a range of 1 μm to 200 μm.

### Claim 9 (depends on 6)

The bone regeneration material according to claim 6, wherein a mass ratio of the octacalcium phosphate particles to the gelatin in the composite is in a range of 1 to 9.

### Claim 10 (depends on 6)

The bone regeneration material according to claim 6, wherein the bone regeneration material maintains a shape retaining property after being subjected to three repeated compressions in each of which the bone regeneration material is compressed to 75% of an original height of the bone regeneration material.