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US 12,599,699 B2Granted
Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation
AssigneeAllergan, Inc.
InventorsXiaojie Yu, Darin J. Messina, Elizabeta Pavlovic, Cunqi Cui, Kate M. Smither
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Abstract
Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.
Claims15
A method of grafting fat in a soft tissue of a human subject, the method comprising:
- (i) injecting a hydrogel component into the soft tissue of the subject, wherein the hydrogel component comprises water and a crosslinked macromolecular matrix, the crosslinked macromolecular matrix comprising a hyaluronic acid component and a silk fibroin component, wherein the hyaluronic acid component is crosslinked to the silk fibroin component by a multiamine cross linker;
- and
- (ii) administering a fat component to the soft tissue of the subject, wherein the fat component contains a lipoaspirate;
- thereby increasing the volume of fat in the soft tissue of the human subject.
1 more element
Dependencies are inferred from the claim text.