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US 12,599,697 B2Granted
Liquid embolic compositions with controlled release of radiopaque and therapeutic compounds and methods of using the same
AssigneeBlackswan Vascular, Inc.
InventorsSuresh S. Pai, Scott R. Sershen, Dorna Hakimimehr, Celso J. Bagaoisan
Life of this patent
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Abstract
The various embodiments of the subject invention included herein provide transiently radiopaque liquid embolic compositions and methods used to embolize blood vessels and/or provide controlled release of therapeutic agents when desired.
Claims13
An embolic composition capable of embolizing a blood vessel comprising:
- an embolic material and one or more compounds of interest,
- wherein the one or more compounds of interest is a combination of therapeutic agent and radiopaque agent that can diffuse out of the embolic composition and diminish the radiopacity of the embolic composition over time;
- wherein all of the compounds of interest are entrapped or sequestered inside a biocompatible, degradable carrier;
- and
- wherein the therapeutic agent is released from the embolic composition in a controlled manner.
2 more elements
A method of use for a liquid embolic composition of the invention capable of embolizing a blood vessel comprising:
- accessing a blood vessel in a living organism via catheter-based devices and methods;
- inserting a delivery catheter at or near a target blood vessel to be embolized;
- injecting a substantially liquid embolic composition comprising an embolic material and one or more compounds of interest into the target blood vessel, wherein the one or more compounds of interest is a combination of therapeutic agent and radiopaque agent that can diffuse out of the embolic composition and diminish the radiopacity of the embolic composition over time, and wherein all of the compounds of interest are entrapped or sequestered inside a biocompatible, degradable carrier;
- and
- releasing the compounds of interest in a controlled manner from the substantially solid embolic composition into the blood vessel or surrounding tissues over time while maintaining permanent embolization of the target vessel.
2 more elements
Dependencies are inferred from the claim text.