Foamable composition for use in surgical diagnostic procedures
AssigneeINX Medical, LLC
InventorsKen Williams, Chrysanthi Williams, Kurt Gampp, Jim Vermeersch
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Abstract
Provided herein are foamable compositions comprising (1) a base, in aqueous suspension, (2) a viscosity modifier component, and (3) a surfactant component. In preferred embodiments, the foamable composition may further comprise a salt. Additional components that may optionally be present in the formable composition include sugars and sugar alcohols, colorants, antioxidants, preservatives, and other excipients generally known to those skilled in the art. Also provided herein are kits for producing a gaseous foam. Also provided herein are methods for detecting the presence of leaks or defects in anatomical tissue or organ.
Claims19
A foamable composition comprising:
- a base selected from the group consisting of sodium bicarbonate and potassium bicarbonate, wherein at least a portion of the base is present as an aqueous suspension;
- a pseudoplastic viscosity modifier selected from the group consisting of gums, polysaccharides, and polyacrylic acids, wherein the pseudoplastic viscosity modifier has a shear yield stress no greater than about 3.5 Pa and a stationary yield stress no less than about 0.1 Pa;
- and
- a surfactant component comprising at least one nonionic surfactant;
- wherein the composition comprises the base in a concentration of at least about 100 mg/mL.
A foamable composition comprising:
- sodium bicarbonate in a concentration of at least about 100 mg/mL, wherein at least a portion of the sodium bicarbonate is present as an aqueous suspension;
- a viscosity modifier comprising xanthan gum;
- and
- a surfactant component comprising at least one polysorbate derived from polyethoxylated sorbitan and oleic acid;
- wherein the mass ratio of the surfactant component to the viscosity modifier is from about 10:1 to about 50:1.
Dependencies are inferred from the claim text.