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US 12,599,666 B2Granted
Photolytic compounds and triplet-triplet annihilation mediated photolysis
AssigneeUniversity of Massachusetts
InventorsGang Han, Ling Huang
Life of this patent
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Abstract
The invention provides novel photolytic compounds and prodrugs, nanoparticles and compositions thereof, and methods of conducting photolysis mediated by triplet-triplet annihilation.
Claims12
A compound having the formula,
- PPG-X,
- wherein
- PPG is a photoremovable protecting group comprising a moiety selected from the group consisting of coumarin, anthracene, perylene and boron-dipyrromethene;
- and
- X is L-Y, wherein L is a photolabile linker comprising an ester, carbonate, carbamate, quaternary ammonium salt moiety and Y a therapeutic moiety.
2 more elements
Alight-activatable prodrug having the structure
- PPG-X,
- wherein
- PPG is a photoremovable protecting group comprising a moiety selected from the group consisting of coumarin, anthracene, perylene and boron-dipyrromethene;
- and
- X is L-Y, wherein L is a photolabile linker comprising an ester, carbonate, carbamate, quaternary ammonium salt moiety and Y an amino acid or peptide moiety.
2 more elements
A composition comprising a pair of a photosensitizer and a photolytic compound, wherein the photosensitizer and the photolytic compound are selected as follows:
- the photosensitizer is capable of light absorption of single low energy photon in the range of about 400 nm to about 1,000 nm thereby reaching a singlet excited state and subsequently generating a photosensitizer triplet excited state through rapid intersystem crossing;
- and
- the triplet excited state is characterized by a lifetime sufficient to allow collision with the photolytic molecule to occur thereby capable of transferring energy to the photolytic molecule via triplet-triplet annihilation so as to cause a photolytic reaction of the photolytic compound,
- wherein the photolytic compound has the formula,
- PPG-X,
- wherein
- PPG is a photoremovable protecting group comprising a moiety selected from the group consisting of coumarin, anthracene, perylene and boron-dipyrromethene;
- and
- X is L-Y, wherein L is a photolabile linker comprising an ester, carbonate, carbamate, quaternary ammonium salt moiety and Y a therapeutic moiety.
6 more elements
Dependencies are inferred from the claim text.