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US 12,599,661 B2Granted
Immunogenic compositions of hepatitis c virus and uses thereof
AssigneeJaw-Ming Cherng
InventorsJaw-Ming Cherng, Jonathan Cherng
Life of this patent
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Abstract
A method for preparing an immunogenic composition, which comprises treating HCV pseudoparticles with α2-3,6,8,9 neuraminidase A to generate the immunogenic composition. In addition, the immunogenic compositions are made in vaccines for eliciting an immune response to HCV in a subject.
Claims4
A method for preparing an immunogenic composition comprising a viral antigen of hepatitis C virus (HCV), which comprises:
- (a) providing HCV pseudoparticles;
- (b) treating the HCV pseudoparticles with α2-3,6,8,9 neuraminidase A to remove sialic acids on the surfaces of the HCV pseudoparticles, and (c) isolating the HCV pseudoparticles produced in step (b) to generate the immunogenic composition.
Dependencies are inferred from the claim text.