Enhancement of vaccine efficacy via biomass and/or related material in animal drink and feed

A method for preventing coccidiosis in a broiler chicken, comprising the steps of:

• selecting a vaccine dose containing between 200 and 3000 sporulated oocysts;
• mixing the vaccine with water at a dosage of 240 ml of water per 1,000 doses to form a vaccine-water combination;
• spraying a one-day old broiler chicken with a dose of the vaccine-water combination;
• forming a lipopolysaccharide/Lipid A treatment compound produced by a gram negative bacteria selected from the group consisting of Variovorax paradoxus and Rhodobacter sphaeroides, the treatment compound having a neutral effect on pathogens, the compound including an active fraction, the compound being formed through the extraction of freeze-dried bacteria and collecting the water layer for freeze-drying, resolubilizing the freeze-dried fraction in water, ultrafiltering the solubilized fraction to remove low molecular weight substances and salts, and affinity purifying the high-molecular weight fraction from which the active fraction is eluted;
• and
• administering an effective amount of the treatment compound in combination with drink or feed to a broiler chicken in vivo to enhance the effectiveness of the vaccine,
• whereby the lipopolysaccharide/Lipid A treatment compound modulates TLR4 activity with a downstream effect being enhancement of the innate and adaptive immune processes of the vaccinated broiler chicken.