US 12,599,651 B2 · Pharmaceuticals and dosing means for human aging reversal

Abstract

A combination of medications and medication doses is disclosed whereby age-related changes in systemic inflammation, cancer risk, heart disease risk, CD38 expression, hair color, thymotrophic hormones, immune cell populations, the CD4/CD8 cell ratio, bone marrow density, thymus structure, kidney function, and epigenetic age can be reversed in humans. Surprisingly, agents that accelerate the growth of cells reduce cancer risk, agents that intensify immune responses attenuate age-related inflammation, agents with no prior connection to hair color reverse age-related hair whitening, and a combination of agents that induces IGF-1, a hormone previously thought to drive systemic aging, results in a reversal of systemic aging as documented by an epigenetic clock. Medication combinations useful in the present invention include human growth hormone (GH) or GH releasers, dehydroepiandrosterone (DHEA), and metformin.

Claims11

Dependent claims

A method for the reversal of human aging, comprising administering a growth hormone (GH) releaser, dehydroepiandrosterone (DHEA), and metformin so as to result in at least one of reduced epigenetic age, reduced prostate specific antigen (PSA), increased percentage of free PSA, increased ratio of free PSA to total PSA, lowered C-reactive protein (CRP) levels, increased hair color, increased IL-7 levels, and increased FGF-21 levels,

wherein the GH releaser increases IGF-1 levels by at least 20% or to at least 170 ng/ml, and
the GH releaser, DHEA, and metformin are administered simultaneously or within two to four hours of one another;
and
the GH releaser is selected from sermorelin, ipamorelin, ghrelin, and growth hormone releasing hormone (GHRH).

1 more element

Dependencies are inferred from the claim text.

Pharmaceuticals and dosing means for human aging reversal

Life of this patent

Pharmaceuticals and dosing means for human aging reversal

Life of this patent

Abstract

Claims11