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US 12,599,634 B2Granted
Nerve guidance conduit comprising neural crest stem-like cells and/or Schwann cell precursor-like cells and methods of making and using the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsAnh D. Le, Qunzhou Zhang
Life of this patent
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Abstract
The present invention includes a functionalized nerve guidance conduit (NGC), methods of making neurotrophic factor-expressing neural crest stem-like cells (NCSC) and/or Schwann cell precursor-like (SCP) cells, methods of making the functionalized nerve guidance conduit, and methods of treating nerve injury using the functionalized nerve guidance conduit.
Claims10
A functionalized nerve guidance conduit (NGC) comprising:
- a decellularized extracellular matrix;
- and
- neurotrophic factor (NTF)-expressing cells generated from gingiva-derived mesenchymal stem cells (GMSCs),
- wherein the NTF-expressing cells are embedded in the decellularized extracellular matrix.
1 more element
Dependencies are inferred from the claim text.