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US 12,599,631 B2Granted
Agent for treating or preventing vascular dementia
AssigneeTohoku University
InventorsKuniyasu Niizuma, Teiji Tominaga
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Abstract
An object is to provide a cell product for treating and/or preventing vascular dementia. The present invention provides a cell product for treating or preventing vascular dementia, containing a SSEA-3-positive pluripotent stem cell (Muse cell) derived from a mesenchymal tissue in a living body or a SSEA-3-positive pluripotent stem cell derived from a cultured mesenchymal cell.
Claims7
A method of treating vascular dementia, comprising:
- intravenously administering an effective amount of a cell product comprising SSEA-3-positive pluripotent human stem cells derived from a mesenchymal tissue in a living body or SSEA-3-positive pluripotent stem cells derived from a cultured mesenchymal cell, to a human vascular dementia patient in need thereof,
- wherein the vascular dementia is vascular dementia without cerebral infarction, and
- wherein the pluripotent stem cell has all of the following characteristics:
- (i) CD105-positive;
- (ii) having low or no telomerase activity;
- (iii) capable of differentiating into any of tridermic cells;
- (vi) showing no neoplastic proliferation;
- and
- (v) having self-renewal capacities.
6 more elements
Dependencies are inferred from the claim text.