Biodegradable lung sealants
AssigneeEthicon, Inc.
InventorsSalim A. Ghodbane, Sridevi Dhanaraj, Brian Aitken
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Abstract
The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.
Claims22
A biodegradable lung sealant comprising:
- a) a first component comprising a first multi-arm PEG and an alkaline buffer solution for reconstituting the first multi-arm PEG;
- b) a second component comprising a second multi-arm PEG and a mildly acidic citrate buffer solution for reconstituting the second multi-arm PEG, the mildly acidic citrate buffer solution having a pH prior to reconstitution of about 4.0 to less than 5.0;
- wherein when components (a) and (b) are combined they produce an adherent and elastic biodegradable lung sealant;
- wherein the first multi-arm PEG is 4-arm PEG-NH2-HCl and the second multi-arm PEG is a PEG-NHS ester;
- and
- wherein a pKa of the alkaline buffer solution is about 7.9 pKa to about 9.7 pKa.
Dependencies are inferred from the claim text.