Compounds to modulate intestinal absorption of nutrients
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
Life of this patent
Estimating the term…
Abstract
This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.
Claims10
A composition formulated for oral administration to a subject, the composition comprising an aluminum cross-linked sulfated agent comprising sucralfate reacted with hydrochloric acid to form an acidified aluminum cross-linked sulfated agent, wherein the composition is in the form of a capsule or a tablet, wherein the capsule or tablet includes an enteric coating formulated to release the acidified aluminum cross-linked sulfated agent in at least a portion of the subject's gastrointestinal tract, and wherein an aluminum/sulfate ratio in the composition is greater than or equal to 1.27 and less than or equal to 1.83.
Dependencies are inferred from the claim text.