Subtituted sulfonylurea and sulfoximineurea derivatives

A compound having the structure of general formula (I)

• or a tautomeric form, stereoisomer, enantiomer, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing said compound wherein
• each of R1 and R2 at each occurrence independently selected from the group consisting of hydrogen, halogen, haloalkyl, cyano, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, (C1-C6)alkyISO2(C1-C6)alkyl, (C1-C6)alkyIN(C1-C6)alkyl, (C1-C6)alkyIN(C3-C7)cycloalkyl, aryl, heteroaryl, heterocyclyl, benzyl, tert-butyloxycarbonyl, thiol, mercaptoalkyl, SO2(C1-C6)alkyl, SO2(C3-C7)cycloalkyl, SO2-aryl, SO2-heterocyclyl, (C1-C6)thioalkyl, (C1-C6)thioalkoxy, (C1-C6)alkyISO2NH2, —CONH2, —CO(C1-C6)alkyl, —CO(C1-C6)haloalkyl, CO(O)(C1-C6)alkyl, —CO-aryl, —CO-heteroaryl, —CO-heterocyclyl, 4- to 7-membered heterocyclic ring, 7- to 14-membered bicyclic heterocyclic ring system, and bridged or spiro ring system having optionally one or more than one heteroatom;
• or, alternatively, R1, R2 and N together may form a saturated or partially saturated 3 to 8 membered heterocyclic ring system, 7- to 14-membered bicyclic heterocyclic ring system, bridged or spiro ring system having optionally one or more than one heteroatom;
• wherein each of R3 and R4 at each occurrence is selected from the group consisting of hydrogen, halogen, haloalkyl, cyano, nitro, amide, sulphonamide, acyl, hydroxyl, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, SO2(C1-C6)alkyl, thiol, mercapto alkyl benzyl, aryl, heteroaryl, and heterocyclyl;
• or, alternatively R3 and R4 may form a bond;
• X is O, N—R6;
• wherein R6 at each occurrence independently is selected from the group consisting of hydrogen, hydroxyl, halogen, nitro, cyano, haloalkyl, and optionally substituted groups selected from (C1-C10)alkyl, (C1-C10)alkoxy, (C3-C10)cycloalkyl, (C2-C10)alkenyl, (C2-C10)alkynyl, SO2(C1-C6)alkyl, thiol, thioalkyl, thio-alkoxy, SO2(C1-C6)alkyl, SO(C1-C6)alkyl, benzyl, aryl, heteroaryl, and heterocyclyl;
• n, is independently selected from integer 0-3;
• wherein
• R5 at each occurrence independently is selected from the group consisting of hydrogen, halogen, haloalkyl, cyano, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, (C3-C7)cycloalkyl, benzyl, aryl, heteroaryl, heterocyclyl, thiol, thioalkyl, thio-alkoxy, SO2(C1-C6)alkyl, SO(C1-C6)alkyl, and bridged or spiro ring system having optionally one or more than one heteroatom;
• ‘A’ is selected from one of the following ring systems
• wherein X, Y, Z at each occurrence independently is selected from the group consisting of C, N, S, SO2, and O, which may be optionally substituted;
• and wherein each of R7, R8, R9, R10, R11 and R12 at each occurrence are independently selected from the group consisting of hydrogen, halogen, cyano, amide, sulphonamide, acyl, hydroxyl, and optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, benzyl, aryl, heteroaryl, and heterocyclyl;
• or, alternatively, each of R8 and R9, R9 and R10, R10 and R11 and R11 and R12 wherever possible, together may form a 4 to 7 membered saturated or partially saturated ring containing from 0-2 additional heteroatoms selected from the group consisting of N, O, and S(O)p;
• wherein p is 1-2.