# US 12,599,601 B2 · Antifungal composition containing carbazole compound as active ingredient

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- Number: US 12,599,601 B2
- Document ID: US12599601B2
- Status: Granted
- Kind: B2
- Application number: 17/771,563
- Filed: 2020-10-16
- Published: 2022-12-01
- Granted: 2026-04-14
- Earliest claimed: 2019-10-23
- Assignees: Korea University Research and Business Foundation
- Applicants: Korea University Research and Business Foundation
- Inventors: Joon Kim; Young Kwang Park
- Web page: https://patentgrep.com/patent/US12599601B2

## CPC

- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A01N 43/38: condensed with carbocyclic rings
- A01N 43/40: six-membered rings
- A01N 43/60: 1,4-Diazines; Hydrogenated 1,4-diazines
- A01P 3/00: Fungicides
- A61K 31/403: condensed with carbocyclic rings, e.g. carbazole
- A61K 31/4045: Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A61K 31/454: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A61K 31/495: having six-membered rings with two {or more} nitrogen atoms as the only ring heteroatoms, e.g. piperazine {or tetrazines}(A61K31/48 takes precedence {; with three nitrogen atoms A61K31/53})
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 31/10: Antimycotics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to an antifungal composition containing a carbazole compound as an active ingredient. The carbazole compound according to the present invention inhibits the growth of not only Candida but also fungi such as yeast, and neutralizes the pathogenicity of Candida by inhibiting morphological transformation thereof. Thus, the carbazole compound is very useful as an antifungal composition capable of treating Candida infection.

## Claims

### Claim 1

A method of killing fungus comprising treating a subject in need of killing the fungus with a carbazole compound selected from the group consisting of Formulas 1, 2, and 4-8:
wherein R1 is Br and R2 is H;
wherein R is H or NO2;

### Claim 2 (depends on 1)

The method of claim 1, wherein the fungus is any one selected from the group consisting of Candida sp., Saccharomyces sp., Kazachstania sp., Aspergillus sp., Cladosporium sp., Penicillium sp. and combinations thereof.

### Claim 3

A method of inhibiting fungal infection comprising treating a fungus-infected subject with a carbazole compound selected from the group consisting of Formulas 1, 2, and 4-8:
wherein R1 is Br and R2 is H;
wherein R is H or NO2;

### Claim 4 (depends on 3)

The method of claim 3, wherein the fungus is any one selected from the group consisting of Candida sp., Saccharomyces sp., Kazachstania sp., Aspergillus sp., Cladosporium sp., Penicillium sp. and combinations thereof.

### Claim 5

A method of treating fungal infection comprising administering an antifungal composition comprising a carbazole compound selected from the group consisting of Formulas 1, 2, and 4-8, to a fungus-infected subject:
wherein R1 is Br and R2 is H;
wherein R is H or NO2;

### Claim 6 (depends on 5)

The method of claim 5, wherein the fungus is any one selected from the group consisting of Candida sp., Saccharomyces sp., Kazachstania sp., Aspergillus sp., Cladosporium sp., Penicillium sp. and combinations thereof.