# US 12,599,600 B2 · Compositions and methods for preventing and treating headache through enhancing 2-arachydonyl glyerol activity

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- Number: US 12,599,600 B2
- Document ID: US12599600B2
- Status: Granted
- Kind: B2
- Application number: 17/331,025
- Filed: 2021-05-26
- Published: 2021-12-02
- Granted: 2026-04-14
- Earliest claimed: 2020-05-29
- Assignees: Arizona Board of Regents on Behalf of the University of Arizona; University of Washington
- Applicants: Arizona Board of Regents on Behalf of the University of Arizona; University of Washington
- Inventors: Tally M. Largent-Milnes; Erika Liktor-Busa; Todd W. Vanderah; Nephi Stella
- Web page: https://patentgrep.com/patent/US12599600B2

## CPC

- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 31/454: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 25/06: Antimigraine agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates generally to compositions and methods for preventing, reducing the occurrence of or treating a headache in a subject in need thereof. In particular, the present invention relates to methods for enhancing 2-arachydonyl glycerol (2AG) tone and reducing prostaglandin activity in a subject for purposes of preventing, reducing the occurrence of or treating a headache (e.g., a migraine headache) in a subject.

## Claims

### Claim 1

A method comprising administering to a human subject suffering from a headache a pharmaceutical composition capable of enhancing arachidonoylglycerol (2AG) tone and/or inhibiting prostaglandin activity in the brain,
wherein the human subject is suffering from a headache characterized with 1) decreased 2AG levels in the periaqueductal grey (PAG) brain region, and 2) unaltered anandamide (AEA) levels in the trigeminal ganglia (TG) brain region,
wherein the pharmaceutical composition capable of enhancing 2AG tone and/or reducing prostaglandin activity in the mammal comprises MJN110 and KT182.

### Claim 2 (depends on 1)

The method of claim 1, wherein the headache is a non-migraine headache.

### Claim 3 (depends on 1)

The method of claim 1, wherein the headache is a migraine headache.

### Claim 4 (depends on 1)

The method of claim 1, wherein the migraine headache is a chronic migraine headache or an episodic migraine headache.

### Claim 5 (depends on 1)

The method of claim 1, further comprising co-administration of a pharmaceutical composition comprising a second agent, wherein the second agent is selected from 5-HT1 agonists, triptans, ergot alkaloids, and non-steroidal anti-inflammatory drugs.