# US 12,599,584 B2 · Indoline derivatives, compositions comprising them and uses thereof

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- Number: US 12,599,584 B2
- Document ID: US12599584B2
- Status: Granted
- Kind: B2
- Application number: 16/071,092
- Filed: 2017-01-19
- Published: 2021-06-10
- Granted: 2026-04-14
- Earliest claimed: 2016-01-21
- Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem; Bar-Ilan University
- Applicants: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.; Bar Ilan University
- Inventors: Marta Weinstock-Rosin; Abraham Nudelman; Shani Zeeli
- Web page: https://patentgrep.com/patent/US12599584B2

## CPC

- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- C07D 209/08: with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A61K 31/4045: Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07D 209/14: Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D 209/18: Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is directed to indoline derivatives and salts thereof, compositions comprising them and uses thereof for the treatment of diseases and disorders associated with at least one of oxidative stress, an immune response, release of NO and release of pro-inflammatory cytokine.

## Claims

### Claim 1

The pharmaceutical composition comprising a compound being the active therapeutic agent being selected from:
and any combinations thereof.