# US 12,599,569 B1 · Encapsulated resveratrol (RSV) nanoparticles

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- Number: US 12,599,569 B1
- Document ID: US12599569B1
- Status: Granted
- Kind: B1
- Application number: 19/004,832
- Filed: 2024-12-30
- Granted: 2026-04-14
- Earliest claimed: 2024-12-30
- Assignees: King Saud University
- Applicants: King Saud University
- Inventors: Mai Abdelrahman Elobeid Wagealla; Atheer Mohammed Asiri; Promy Virk; Manal Ahmed Gasmelseed Awad
- Web page: https://patentgrep.com/patent/US12599569B1

## CPC

- A61K 9/5036: {Polysaccharides, e.g. gums, alginate; Cyclodextrin}
- A61K 9/5026: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates}
- A61K 9/5138: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates}
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Encapsulated resveratrol (RSV) nanoparticles having a resveratrol core, a gum arabic shell, and a polyvinyl alcohol coating over the gum arabic shell. In an embodiment, an RSV:gum arabic:polyvinyl alcohol (PVA) ratio in the encapsulated nanoparticles is about 1:5:5 (w/w/w). The encapsulated RSV nanoparticles can have an average size ranging from about 195 nm to about 210 nm.

## Claims

### Claim 1

Encapsulated resveratrol (RSV) nanoparticles, consisting of:
a resveratrol core;
a gum arabic shell over the resveratrol core; and
a polyvinyl alcohol coating over the gum arabic shell.

### Claim 2 (depends on 1)

The encapsulated resveratrol (RSV) nanoparticles of claim 1, wherein an RSV:gum arabic:polyvinyl alcohol (PVA) ratio in the encapsulated nanoparticles is about 1:5:5 (w/w/w).

### Claim 3 (depends on 1)

The encapsulated resveratrol (RSV) nanoparticles of claim 1, wherein the nanoparticles have an average size ranging from about 195 nm to about 210 nm.

### Claim 4 (depends on 3)

The encapsulated resveratrol (RSV) nanoparticles of claim 3, wherein the encapsulated resveratrol (RSV) nanoparticles have an average size of about 207.8 nm.

### Claim 5 (depends on 1)

The encapsulated resveratrol (RSV) nanoparticles of claim 1, wherein the encapsulated resveratrol (RSV) nanoparticles have a polydispersity index (PDI) ranging from about 0.195 to about 0.225.

### Claim 6 (depends on 5)

The encapsulated resveratrol (RSV) nanoparticles of claim 5, wherein the encapsulated resveratrol (RSV) nanoparticles have a polydispersity index (PDI) of about 0.222.

### Claim 7 (depends on 1)

The encapsulated resveratrol (RSV) nanoparticles of claim 1, wherein the encapsulated resveratrol (RSV) nanoparticles are spherical.

### Claim 8

Encapsulated resveratrol (RSV) nanoparticles, consisting of:
a resveratrol core;
a gum arabic shell over the resveratrol core; and
a polyvinyl alcohol coating over the gum arabic shell, wherein a ratio of the RSV:gum arabic:polyvinyl alcohol (PVA) ratio in the encapsulated nanoparticles is about 1:5:5 (w/w/w).

### Claim 9 (depends on 8)

The encapsulated resveratrol (RSV) nanoparticles of claim 8, wherein the encapsulated resveratrol (RSV) nanoparticles have an average size ranging from about 195 nm to about 210 nm.

### Claim 10 (depends on 8)

The encapsulated resveratrol (RSV) nanoparticles of claim 8, wherein the encapsulated resveratrol (RSV) nanoparticles are spherical.

### Claim 11 (depends on 8)

The encapsulated resveratrol (RSV) nanoparticles of claim 8, wherein the encapsulated resveratrol (RSV) nanoparticles have a polydispersity index (PDI) ranging from about 0.195 to about 0.225.