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US 12,599,568 B2Granted
Softgel capsules having a fill composition comprising magnesium oxide
AssigneeCaptek Softgel International, Inc.
InventorsDiana Paik Lee, Hong Anh Nguyen, Timothy Brian Chiprich, John Puckett, Bibu Phillip George
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Abstract
Softgel capsules have a fill composition that administers a 200 to 500 mg dose of magnesium from magnesium oxide and an outer sofgel gelatin shell. The composition includes 55 to 70% w/w of an edible oil, 2 to 8% w/w polysorbate 80, 0.5 to 2% w/w hydrophobic silica, and 0.2 to 4% w/w of a chelating agent for binding to magnesium. The softgel capsules have a dissolution according to USP <711> of greater than NLT 75% (Q).
Claims12
A softgel capsule comprising:
- a fill composition comprising:
- 200 to 500 mg dose of magnesium from magnesium oxide;
- 55 to 70% w/w of an edible oil;
- 2 to 8% w/w polysorbate 80;
- 0.5 to 2% w/w hydrophobic silica;
- and
- 0.2 to 4% w/w of a chelating agent for binding to magnesium comprising ethylenediaminetetraacetic acid (EDTA) and/or an EDTA salt, and optionally a weak acid;
- and
- an outer softgel gelatin shell encapsulating the fill material;
- wherein the softgel capsule has a dissolution according to United States Pharmacopeia (USP) <711> of greater than 75% for the magnesium oxide.
7 more elements
Dependencies are inferred from the claim text.