Formulation
AssigneeHewlett Healthcare Ltd
InventorNigel Cooper
Life of this patent
Estimating the term…
Abstract
A composition, for example an oil-in-water emulsion, comprising an amphoteric surfactant, alkoxylated cetyl alcohol, a polar dmg and a preservative, wherein the total amount of preservative present in the composition is about 0.2% w/w or less and is not benzyl alcohol and/or triclosan. The drug may be sodium cromoglicate and/or nedocromil sodium. The formulation may be useful in the treatment of skin diseases such as atopic dermatitis.
Claims18
A composition for topical administration for use in treating a skin disease or condition, wherein the skin disease or condition involves skin mast cells, delayed hypersensitivity reactions, or inflammation, or is selected from atopic dermatitis, eczema, contact sensitivity, psoriasis, drug sensitivity reactions, aphthous ulcers, pemphigus, urticaria, urticaria pigmentosa, pyoderma gangrenosum, skin ulcers associated with Crohn's disease, burns, insect stings/bites, morphoea, and sunburn, or a combination thereof, and wherein the composition comprises sodium cromoglicate, an amphoteric surfactant, and an alkoxylated cetyl alcohol, wherein the total amount of a preservative present in the composition is about 0.2% w/w or less wherein the preservative is chlorocresol and is not one or more of benzyl alcohol and triclosan.
A composition for topical administration comprising:
- a) sodium cromoglicate;
- b) an amphoteric surfactant;
- c) an alkoxylated cetyl alcohol, and
- d) a preservative in an amount selected from
- i) about 0.001% to about 0.2% w/w of the composition,
- ii) about 0.01% to about 0.15% w/w of the composition, or
- iii) about 0.1% w/w of the composition;
- wherein the preservative is chlorocresol and is not one or more of benzyl alcohol and triclosan.
A composition for treating a skin disease or condition selected from the group consisting of one or more of atopic dermatitis, eczema, contact sensitivity, psoriasis, urticaria, urticaria pigmentosa, burns, and sunburn, comprising administering a composition comprising:
- sodium cromoglicate, an amphoteric surfactant, and an alkoxylated cetyl alcohol, wherein the total amount of a preservative present in the composition is about 0.2% w/w or less, wherein the preservative is chlorocresol and is not one or more of benzyl alcohol and triclosan.
A method of treating a skin disease or condition selected from the group consisting of one or more of atopic dermatitis, eczema, contact sensitivity, psoriasis, urticaria, urticaria pigmentosa, burns, and sunburn, comprising administering a composition comprising:
- sodium cromoglicate, an amphoteric surfactant, and an alkoxylated cetyl alcohol, wherein the total amount of a preservative present in the composition is about 0.2% w/w or less, wherein the preservative is chlorocresol and is not one or more of benzyl alcohol and triclosan.
Dependencies are inferred from the claim text.