# US 12,599,548 B2 · Method of treating oxidative stress in skin and compositions therefor

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- Number: US 12,599,548 B2
- Document ID: US12599548B2
- Status: Granted
- Kind: B2
- Application number: 18/732,895
- Filed: 2024-06-04
- Published: 2024-09-26
- Granted: 2026-04-14
- Earliest claimed: 2020-12-14
- Assignees: The Procter & Gamble Company
- Applicants: The Procter & Gamble Company
- Inventors: Tomohiro Hakozaki; Leo Timothy Laughlin, II; Matthew Clair Ehrman; XiPing Ng
- Web page: https://patentgrep.com/patent/US12599548B2

## CPC

- A61K 8/604: {Alkylpolyglycosides; Derivatives thereof, e.g. esters}
- A61Q 19/00: Preparations for care of the skin
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/60: Sugars; Derivatives thereof
- A61K 8/675: {Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678)}
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/522: Antioxidants; Radical scavengers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Cellular energy levels in skin cells affected by oxidative stress can be improved through the use of a skin care composition that includes a sucrose ester and a fatty alcohol present at a specific ratio. The fatty alcohol and sucrose ester, when incorporated into a skin care composition at a specific ratio, can provide a synergistic improvement in cellular ATP level for skin cells suffering from the effects of oxidative stress.

## Claims

### Claim 1

A skin care composition, comprising:
a) a sucrose ester chosen from sucrose laurate, sucrose dilaurate, sucrose trilaurate, or mixtures thereof;
b) hexyldecanol; and
c) a dermatologically acceptable carrier, wherein the fatty alcohol and sucrose ester are present at a weight ratio of 1:1 to 5:1, based on the weight of the composition, and the combination of sucrose ester and fatty alcohol has a synergy factor of at least 1.1 according to the Oxidative Stress Test.

### Claim 2 (depends on 1)

The skin care composition of claim 1, wherein the sucrose ester comprises a mixture of sucrose laurate and sucrose dilaurate.

### Claim 3 (depends on 2)

The skin care composition of claim 2, wherein sucrose laurate is present at about 55% to about 80%, by weight of the sucrose ester and the sucrose dilaurate is present at about 20% to about 45% by weight of the sucrose ester.

### Claim 4 (depends on 1)

The skin care composition of claim 1, wherein the composition further comprises at least one additional ingredient chosen from vitamins, minerals, peptides, sugar amines, sunscreen agents, oil control agents, flavonoid compounds, anti-oxidants, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizing agents, exfoliating agents, skin lightening agents, lubricants, anti-acne actives, chelating agents, anti-wrinkle actives, anti-atrophy actives, phytosterols, N-acyl amino acid compounds, antimicrobials, and antifungals, conditioning agents, emulsifiers, rheology modifiers, or mixtures thereof.

### Claim 5 (depends on 4)

The skin care composition of claim 4, wherein the additional ingredient is a skin care active chosen from vitamin B3 compounds, undecylenoyl phenylalanine, vitamin E compounds, palmitoylated dipeptides, palmitoylated pentapeptides, vitamin A compounds, or mixtures thereof.

### Claim 6 (depends on 4)

The skin care composition of claim 4, wherein the composition further comprises a rheology modifier chosen from the group consisting of acrylates/C10-30 alkyl acrylate crosspolymer, acrylates vinyl isodeconate crosspolymers, polyacrylate crosspolymer-6, sodium polyacryloyldimethyl taurate, or mixtures thereof.

### Claim 7 (depends on 4)

The skin care composition of claim 4, wherein the composition further comprises an emulsifier chosen from glycereth-25 pyrrolidonecarboxylic acid isostearate, PEG-100 stearate, steareth-2, steareth-21, or mixtures thereof.

### Claim 8 (depends on 1)

A method of improving cellular energy levels in skin cells affected by oxidative stress, comprising:
a) identifying a target portion of skin where treatment is desired; and
b) applying the skin care composition of claim 1.

### Claim 9 (depends on 8)

The method of claim 8, wherein the sucrose ester and the fatty alcohol are each present at about 0.0001% to about 10%, by weight of the composition.

### Claim 10 (depends on 8)

The method of claim 8, wherein the fatty alcohol is present at about 0.0001% to about 10%, by weight of the composition.

### Claim 11 (depends on 8)

The method of claim 8, wherein the target portion of skin exhibits a sign of oxidative stress and the composition is applied over the course of a treatment period.

### Claim 12 (depends on 11)

The method of claim 11, wherein the treatment period is at least 4 weeks and the composition is applied at least once per day.