Topical compositions optimised for epidermal lipids and phosphatidyl gycerol

A method for treating damage to the skin barrier layer comprising administering to a subject in need thereof a topical composition comprising as an active agent an association comprising:

• a) at least one ceramide;
• b) at least one saturated fatty acid C12-C22;
• and
• c) cholesterol;
• said topical composition comprising phosphatidylglycerol,
• wherein:
• said components a), b) and c) and phosphatidylglycerol are dispersed as such within said topical composition;
• the phospatidylglycerol is present in a weight ratio with respect to said ceramide comprised between 1:4 and 2:4,
• weight ratios of the a/b/c components selected from 3:1:1, and 2:1:1.

A method for treating skin of elderly subjects comprising administering to said subjects a topical composition comprising as an active agent an association comprising:

• a) at least one ceramide;
• b) at least one saturated C12-C22fatty acid;
• and
• c) cholesterol,
• said topical composition comprising phosphatidylglycerol,
• wherein:
• said components a), b) and c) and phosphatidylglycerol are dispersed as such within said topical composition;
• the phosphatidylglycerol is present in a weight ratio with respect to said ceramide comprised between 1:4 and 2:4,
• weight ratios a/b/c is 1:2:1.