# US 12,599,430 B2 · Systems and methods for perivascular nerve denervation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,599,430 B2 - Document ID: US12599430B2 - Status: Granted - Kind: B2 - Application number: 17/190,161 - Filed: 2021-03-02 - Published: 2021-06-17 - Granted: 2026-04-14 - Earliest claimed: 2016-09-07 - Assignees: Deepqure Inc. - Applicants: DeepQure Inc. - Inventors: Chang Wook Jeong; Du Jin Bach - Web page: https://patentgrep.com/patent/US12599430B2 ## CPC - A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)} - A61L 29/02: Inorganic materials - A61L 29/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds - A61B 2017/00867: {shape memory effect} - A61B 2018/00404: {Blood vessels other than those in or around the heart} - A61B 2018/00434: {Neural system} - A61B 2018/00511: {Kidney} - A61B 2018/00714: {Temperature} - A61B 2018/00791: {Temperature} - A61B 2018/00875: {Resistance or impedance} - A61B 2018/00982: {combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes} - A61B 2018/1407: {Loop} - A61B 2018/142: {at least partly surrounding the target, e.g. concave, curved or in the form of a cave} - A61B 2018/1467: {using more than two electrodes on a single probe} - A61L 2400/16: Materials with shape-memory or superelastic properties - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract Provided is a catheter including a shaft having a distal end and a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue. The loop includes: a first film capable of bending to curl around the tissue and a plurality of electrodes disposed on the first film and made of a two-way shape-memory alloy. ## Claims ### Claim 1 A catheter apparatus for perivascular nerve denervation, comprising: a shaft having a distal end; and a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue, wherein the loop is configured to curl as the loop emerges distally from the distal end of the shaft and includes: a first film capable of bending to curl around the tissue and a plurality of electrodes disposed on the first film and the plurality of electrodes are made of a two-way shape-memory alloy, wherein the plurality of electrodes include a first electrode extended along a direction in which the loop is configured to emerge from the shaft to deliver thermal energy to a first treatment zone of the tissue and a second electrode extended along the direction in which the loop is configured to emerge from the shaft to deliver thermal energy to a second treatment zone of the tissue, and wherein when the energy is received by the first electrode and the second electrode, the first electrode and the second electrode localize heat distribution between the first electrode and the second electrode so that the thermal energy delivered by the first electrode and the second electrode is localized between the first treatment zone and the second treatment zone. ### Claim 2 (depends on 1) The catheter apparatus of claim 1, wherein the two-way shape-memory alloy is curved at a first curvature at a temperature above a first transformation temperature and is curved at a second curvature at a temperature above a second transformation temperature. ### Claim 3 (depends on 2) The catheter apparatus of claim 2, wherein the loop is configured to curl at the first curvature by the plurality of electrodes as the plurality of electrodes is heated to the first transformation temperature by body temperature. ### Claim 4 (depends on 2) The catheter apparatus of claim 2, wherein the loop is configured to curl at the second curvature by the plurality of electrodes as the plurality of electrodes is heated to the second transformation temperature by delivering the energy to the plurality of electrodes. ### Claim 5 (depends on 2) The catheter apparatus of claim 2, wherein the second curvature is smaller than the first curvature. ### Claim 6 (depends on 2) The catheter apparatus of claim 2, wherein the first transformation temperature is set between 35° C. and 45° C. and the second transformation temperature is set between 50° C. and 60° C. ### Claim 7 (depends on 2) The catheter apparatus of claim 2, wherein the two-way shape-memory alloy is uncurled in a straight shape below a third transformation temperature, and the third transformation temperature is set between 20° C. and 25° C. ### Claim 8 (depends on 1) The catheter apparatus of claim 1, wherein the loop further includes a second film on which the first film is disposed. ### Claim 9 (depends on 1) The catheter apparatus of claim 1, wherein the loop further includes a sensor disposed thereon and configured to sense at least one of an impedance of the plurality of electrodes or a temperature of the tissue. ### Claim 10 (depends on 8) The catheter apparatus of claim 8, wherein the first film is a polyimide film, and the second film is a biocompatible heat-treated stainless steel plate. ### Claim 11 (depends on 8) The catheter apparatus of claim 8, wherein the loop further includes a third film on which the second film is disposed. ### Claim 12 (depends on 1) The catheter apparatus of claim 1, wherein the tissue includes at least one of a nerve, lymphatics or capillaries around an artery.