Methods for controlling treatment volumes, thermal gradients, muscle stimulation, and immune responses in pulsed electric field treatments
AssigneeNorth Carolina State University
InventorsMichael Benjamin Sano, Christopher Fesmire, Ross A. Petrella
Life of this patent
Estimating the term…
Abstract
Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.
Claims20
A method of performing electronically controlled electrotherapy comprising modifying or killing target cells of a target tissue and simultaneously modifying a secondary outcome by delivering electrical pulses to the target tissue and dynamically adjusting an energy delivery rate of the electrical pulses in response to a measurement,
- wherein the secondary outcome comprises at least one of a physical outcome, a biological outcome, or a systemic outcome, and
- wherein dynamically adjusting the energy delivery rate of the electrical pulses comprises increasing a width of at least one of the electrical pulses in response to the measurement indicating that a temperature of the target tissue is below a threshold value, to thereby increase the temperature of the target tissue.
A method of performing electronically controlled electrotherapy comprising:
- delivering a plurality of electrical pulses to a target tissue of a patient;
- and
- modifying or killing target cells of the target tissue and simultaneously reducing or eliminating muscle contractions of the patient by adjusting an energy delivery rate of the electrical pulses in response to at least one of a user input, a measurement from one or more sensors, or a measurement from imaging,
- wherein adjusting the energy delivery rate of the electrical pulses comprises reducing a delay between ones of the electrical pulses in response to the at least one of the user input, the measurement from the one or more sensors, or the measurement from the imaging, to thereby reduce or eliminate muscle contractions of the patient.
A method of performing electronically controlled electrotherapy comprising:
- delivering a plurality of electrical pulses to a target tissue of a patient;
- and
- modifying or killing target cells of the target tissue and simultaneously adjusting an energy delivery rate of the electrical pulses in response to an impedance measurement of the target tissue received from one or more sensors,
- wherein adjusting the energy delivery rate of the electrical pulses comprises increasing the energy delivery rate in response to the impedance measurement of the target tissue being above a threshold value.
Dependencies are inferred from the claim text.