# US 12,599,425 B2 · Systems for perivascular nerve denervation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,599,425 B2 - Document ID: US12599425B2 - Status: Granted - Kind: B2 - Application number: 17/113,935 - Filed: 2020-12-07 - Published: 2021-03-25 - Granted: 2026-04-14 - Earliest claimed: 2016-09-07 - Assignees: Deepqure Inc. - Applicants: DeepQure Inc. - Inventors: Chang Wook Jeong; Seok Joo Chang; Du Jin Bach - Web page: https://patentgrep.com/patent/US12599425B2 ## CPC - A61B 18/082: {Probes or electrodes therefor} - A61B 17/320068: {using mechanical vibrations, e.g. ultrasonic (A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745)} - A61B 18/02: by cooling, e.g. cryogenic techniques - A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)} - A61B 18/24: with a catheter (A61B18/26, A61B18/28 take precedence) - A61B 17/22012: {in direct contact with, or very close to, the obstruction or concrement (for removing obstructions in blood vessels by laser A61B18/245)} - A61B 2018/00083: {low, i.e. electrically insulating} - A61B 2018/00184: {Moving parts} - A61B 2018/00345: {Vascular system} - A61B 2018/00434: {Neural system} - A61B 2018/00511: {Kidney} - A61B 2018/00791: {Temperature} - A61B 2018/00875: {Resistance or impedance} - A61B 2018/0212: {using an instrument inserted into a body lumen, e.g. catheter} - A61B 2018/126: {bipolar} - A61B 2018/1407: {Loop} - A61B 2018/142: {at least partly surrounding the target, e.g. concave, curved or in the form of a cave} - A61B 2018/1467: {using more than two electrodes on a single probe} - A61B 2018/1475: {Electrodes retractable in or deployable from a housing} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Provided is a catheter including a shaft having a distal end and a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue. The loop includes: a first film capable of bending to curl around the tissue; a plurality of electrodes disposed on the first film and arranged in parallel to each other with a predetermined distance; a sensor disposed at a position corresponding to a position between the plurality of electrodes. ## Claims ### Claim 1 A catheter apparatus for perivascular nerve denervation, comprising: a shaft having a distal end; and a loop disposed near the distal end and configured to curl so as to contact a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue, wherein the loop is configured to curl onto itself as the loop emerges distally from the distal end of the shaft and includes: a first film capable of bending to curl around the tissue; a plurality of electrodes disposed on the first film and arranged in parallel to each other with a predetermined distance and configured to curl to directly contact the tissue; and a sensor disposed at a position corresponding to a position between the plurality of electrodes, and wherein the plurality of electrodes includes a first electrode extending along a direction in which the loop is configured to emerge from the shaft, the first electrode configured to deliver thermal energy to a first treatment zone of the tissue, and a second electrode extending along the direction in which the loop is configured to emerge from the shaft, the second electrode configured to deliver thermal energy to a second treatment zone of the tissue, and wherein when the energy is received by the first electrode and the second electrode, the first electrode and the second electrode localize heat distribution between the first electrode and the second electrode so that the thermal energy delivered by the first electrode to the first treatment zone and the thermal energy delivered by the second electrode to the second treatment zone is localized between the first treatment zone and the second treatment zone. ### Claim 2 (depends on 1) The catheter apparatus of claim 1, wherein the plurality of electrodes are is configured to form a bipolar configuration to localize the thermal energy delivered by the first electrode to the first treatment zone and the thermal energy delivered by the second electrode to the second treatment zone. ### Claim 3 (depends on 1) The catheter apparatus of claim 1, wherein the loop further includes a second film on which the first film is disposed. ### Claim 4 (depends on 3) The catheter apparatus of claim 3, wherein the sensor is disposed on the second film. ### Claim 5 (depends on 3) The catheter apparatus of claim 3, wherein the first film is a polyimide film, and the second film is a biocompatible heat-treated stainless steel plate. ### Claim 6 (depends on 3) The catheter apparatus of claim 3, wherein the loop further includes a third film on which the second film is disposed. ### Claim 7 (depends on 1) The catheter apparatus of claim 1, wherein the energy received by the loop is at least one selected from the group consisting of radio-frequency (RF) energy and electrical energy. ### Claim 8 (depends on 1) The catheter apparatus of claim 1, wherein the sensor is electrically insulated from the plurality of electrodes and is configured to sense at least one of an impedance of the plurality of electrodes or a temperature of the tissue. ### Claim 9 (depends on 1) The catheter apparatus of claim 1, wherein the tissue includes at least one of a nerve, lymphatics, or capillaries around an artery. ### Claim 10 A method for perivascular nerve denervation using a catheter apparatus, the catheter apparatus comprising a shaft having a distal end and a loop disposed near the distal end and configured to curl so as to contact a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue, wherein the loop is configured to curl onto itself as the loop emerges distally from the distal end of the shaft and includes a first film capable of bending to curl around the tissue, a plurality of electrodes disposed on the first film and arranged in parallel to each other with a predetermined distance and configured to curl to directly contact the tissue and a sensor disposed at a position corresponding to a position between the plurality of electrodes, wherein the plurality of electrodes includes a first electrode extending along a direction in which the loop is configured to emerge from the shaft, the first electrode configured to deliver thermal energy to a first treatment zone of the tissue, and a second electrode extending along the direction in which the loop is configured to emerge from the shaft, the second electrode configured to deliver thermal energy to a second treatment zone of the tissue, and wherein when the energy is received by the first electrode and the second electrode, the first electrode and the second electrode localize heat distribution between the first electrode and the second electrode so that the thermal energy delivered by the first electrode to the first treatment zone and the thermal energy delivered by the second electrode to the second treatment zone is localized between the first treatment zone and the second treatment zone, and the method comprises: positioning the loop near the tissue, delivering the energy to the plurality of electrodes, thereby to cause the loop to curl around the tissue; causing the plurality of electrodes to convert the energy into the thermal energy delivered to the first treatment zone and the thermal energy delivered to the second treatment zone; and denervating at least the portion of the tissue using the thermal energy delivered to the first treatment zone and the thermal energy delivered to the second treatment zone. ### Claim 11 (depends on 10) The method of claim 10, wherein the plurality of electrodes are configured to form a bipolar configuration to localize the thermal energy delivered by the first electrode to the first treatment zone and the thermal energy delivered by the second electrode to the second treatment zone 2-3. ### Claim 12 (depends on 10) The method of claim 10, wherein the tissue includes at least one of a nerve, lymphatics or capillaries around an artery. ### Claim 13 (depends on 10) The method of claim 10, further comprising: sensing an impedance of the plurality of electrodes or a temperature of the tissue through the sensor.