# US 12,599,386 B2 · Devices, systems, and methods for treating the left atrial appendage

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- Number: US 12,599,386 B2
- Document ID: US12599386B2
- Status: Granted
- Kind: B2
- Application number: 17/006,660
- Filed: 2020-08-28
- Published: 2021-04-22
- Granted: 2026-04-14
- Earliest claimed: 2019-03-25
- Assignees: Laminar, Inc.
- Applicants: Laminar, Inc.
- Inventors: Randall T. Lashinski; Joshua J. Dwork
- Web page: https://patentgrep.com/patent/US12599386B2

## CPC

- A61B 17/12122: {within the heart (for closing a cardiac septal defect A61B17/0057)}
- A61B 17/0644: {penetrating the tissue, deformable to closed position}
- A61B 17/12013: {for use in minimally invasive surgery, e.g. endoscopic surgery}
- A61B 17/12031: {complete occlusion}
- A61B 17/12136: {Balloons}
- A61B 17/1214: {Coils or wires}
- A61B 17/12145: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)}
- A61B 17/12159: {Solid plugs; being solid before insertion}
- A61B 17/12168: {having a mesh structure (A61B17/1214 takes precedence)}
- A61B 17/12172: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)}
- A61B 17/0643: {with separate closing member, e.g. for interlocking with staple}
- A61B 17/068: Surgical staplers {, e.g. containing multiple staples or clamps}({staplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105;} for performing anastomosis A61B17/115; {staplers in general B25C5/00})
- A61B 17/0682: {for applying U-shaped staples or clamps, e.g. without a forming anvil}
- A61B 17/122: Clamps or clips, e.g. for the umbilical cord {(for the vas deferens A61F6/206)}
- A61B 2017/00243: {cardiac}
- A61B 2017/00292: {mounted on or guided by flexible, e.g. catheter-like, means}
- A61B 2017/00367: {Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like}
- A61B 2017/00477: {Coupling (A61B2017/0046 takes precedence)}
- A61B 2017/00632: {Occluding a cavity, i.e. closing a blind opening}
- A61B 2017/00867: {shape memory effect}
- A61B 2017/00876: {magnetic}
- A61B 2017/0641: {having at least three legs as part of one single body}
- A61B 2017/0647: {having one single leg, e.g. tacks}
- A61B 2017/0649: {Coils or spirals}
- A61B 2017/081: {Tissue approximator (A61B2017/1103, A61B17/8866 take precedence)}
- A61B 2017/1205: {Introduction devices}
- A61B 2017/12054: {Details concerning the detachment of the occluding device from the introduction device}
- A61B 2017/12095: {Threaded connection}
- A61B 2017/22042: {Details of the tip of the guide wire}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Disclosed are embodiments of a method for occluding a left atrial appendage (LAA) and other cavities or openings within a body. Some embodiments of the method can include an implant configured to be deployed within the LAA or other cavity, configured to be expanded or moved against a wall portion of the LAA or other cavity, and configured to twist at least a portion of the LAA or other cavity when the implant is rotated. Thereafter, one or more securing elements, staples, sutures, or other fasteners can be implanted in the gathered tissue to hold the tissue in the gathered state, thereby occluding the opening of the LAA or other cavity. In some embodiments, the opening of the LAA or other cavity can be occluded by elongating or otherwise reshaping the opening using an implant device, and securing the opening in the occluded state.

## Claims

### Claim 1

A device for closing or occluding a cavity or vessel, comprising:
an implant configured to move between a first state and a second state, the implant including a plurality of tissue anchors and a locking mechanism; and
a catheter configured to cause the implant to move from the first state to the second state so that an outside surface of the implant moves against an inner wall surface of the cavity or vessel after the implant has been advanced into the cavity or vessel;
wherein the catheter has a shaft removably coupled with the implant, the catheter defining a longitudinal axis, the catheter being configured to rotate the implant in a first direction from a first position to a second position about the longitudinal axis, the plurality of tissue anchors being positioned and oriented to engage tissue of the cavity or vessel when the implant is rotated in the first direction about the longitudinal axis and thereby cause at least a portion of the cavity or vessel to constrict around an outside surface of the implant when the implant is in the second state and to reduce a volume of space within the cavity or vessel, wherein the locking mechanism is configured to maintain the second position upon removal of the catheter.

### Claim 2 (depends on 1)

The device of claim 1, further comprising a securing element having one or more arms extending away from a body portion of the securing element, the securing element being configured to prevent a rotation of at least a portion of the cavity or vessel in a second direction when the securing element is in an operable state, wherein the second direction is opposite to the first direction.

### Claim 3 (depends on 1)

The device of claim 1, further comprising a securing element having one or more arms extending away from a body portion of the securing element, the securing element being configured to move at least from a first state in which the one or more arms are collapsed and a second state in which the one or more arms are expanded such that an end portion of each of the one or more arms are spaced further apart from the body portion of the securing element when the securing element is in the second state than when the securing element is in the first state.

### Claim 4 (depends on 3)

The device of claim 3, wherein the one or more arms of the securing element are configured to extend toward the implant when the securing element is in the second state.

### Claim 5 (depends on 1)

The device of claim 1, wherein the implant is self-expandable such that the implant automatically moves from the first state to the second state when a restraint is removed from the implant.