# US 12,599,310 B2 · Device, method and systems for providing imaging of one or more aspects of blood perfusion

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- Number: US 12,599,310 B2
- Document ID: US12599310B2
- Status: Granted
- Kind: B2
- Application number: 18/267,932
- Filed: 2021-12-07
- Published: 2024-02-01
- Granted: 2026-04-14
- Earliest claimed: 2020-12-17
- Assignees: Koninklijke Philips N.V.
- Applicants: Koninklijke Philips N.V.
- Inventors: Willem Verkruijsse; Mark Josephus Henricus van Gastel; Age Jochem van Dalfsen
- Web page: https://patentgrep.com/patent/US12599310B2

## CPC

- A61B 5/0261: {using optical means, e.g. infrared light}
- A61B 5/02427: {Details of sensor}
- A61B 5/1075: {for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer (A61B8/0858 takes precedence)}
- A61B 5/489: {Blood vessels}
- G16H 30/40: for processing medical images, e.g. editing
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

The present invention relates to a device (100), systems (500, 500′, 500″) and a method for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region (12) of a subject. Current perfusion imaging systems use either photoplethysmography (PPG) or speckle contrast (SC), but a problem of both techniques is that considerable ambiguity exists because the source of the signal (volume pulsatility in PPG or blood flow in SC) is unknown. The present invention is based on the idea of combining two different types of measurement, namely widefield imaging and radial imaging, in order to estimate the source depth (20) of the signal to provide more accurate PPG imaging and SC imaging.

## Claims

### Claim 1

Device for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject, said device comprising a processing unit configured to:
obtain data streams derived from detected electromagnetic radiation transmitted through or reflected from the skin region, said data streams comprising a data signal per skin pixel for a plurality of skin pixels of the skin region, wherein a first data stream is derived from radial imaging of the skin region and a second data stream is derived from widefield imaging the skin region, wherein both the first data stream and the second data stream are acquired at substantially the same wavelength;
determine, per skin pixel or group of skin pixels, from the data signals of the first data stream and the second data stream, optical depth indices, ODIs, by dividing, per skin pixel or group of skin pixels, data signals of the first data stream by data signals of the second data stream, wherein the ODIs are indicative of the depth of the blood flow within the skin region at the skin pixels or groups of skin pixels;
create an ODI image map of the skin region including the plurality of skin pixels from the determined ODIs;
create an amplitude image map of the skin region including the plurality of skin pixels from amplitudes of the data signals of the second data stream; and
correct the amplitude image map by correcting, per skin pixel or group of skin pixels, the amplitudes of the data signals of the second data stream by the determined ODIs.

### Claim 2 (depends on 1)

Device according to claim 1, wherein the processing unit is configured to correct the amplitude image map by estimating source depths of the blood flow within the skin region at the skin pixels or groups of skin pixels from the determined ODIs and by correcting, per skin pixel or group of skin pixels, the amplitudes of the data signals of the second data stream by the estimated source depths of the blood flow.

### Claim 3 (depends on 2)

Device according to claim 2, wherein the amplitudes of the data signals of the second data stream are proportional to exp (−2μaSD), where μa is a predetermined tissue attenuation coefficient and SD is the estimated source depth of the blood motion within the skin region at a skin pixel or a group of skin pixels.

### Claim 4 (depends on 1)

Device according to claim 1, wherein the processing unit is configured to derive, in case of a patterned illumination, the data signals of the second data stream by a spatial integral of the electromagnetic radiation transmitted through or reflected from the skin region.

### Claim 5 (depends on 1)

Device according to claim 1, wherein the data signals of the first and second data stream comprise time-varying AC components and constant DC components, and wherein the processing unit is configured to create the amplitude image map by determining, per skin pixel or group of skin pixels, ratios of the time-varying AC components and the constant DC components of the data signals of the second data stream.

### Claim 6 (depends on 5)

Device according to claim 5, wherein the processing unit is configured to determine, per skin pixel or group of skin pixels, the ODIs from the data signals of the first and second data stream by dividing, per skin pixel or group of skin pixels, ratios of the time-varying AC components and the constant DC components of the data signals of the first data stream by ratios of the time-varying AC components and the constant DC components of the data signals of the second data stream.

### Claim 7 (depends on 6)

Device according to claim 6, wherein the processing unit is further configured to determine, per skin pixel or group of skin pixels, the ODIs by selecting values of the ratios of the time-varying AC components and the constant DC components of the data signals of the first data stream at predetermined radial distances between the skin pixels or groups of skin pixels and illumination spots of the patterned illumination.

### Claim 8 (depends on 1)

Device according to claim 1, wherein the data signals of the first and second data stream comprise pulsatile components and/or constant components, the pulsatile components representing the cardiac induced pulsatile blood motion in vessels of the skin region and the constant components representing the averaged non-pulsatile blood motion in vessels of the skin region, and wherein the processing unit is configured to create the amplitude image map from the pulsatile or constant components of the data signals of the second data stream.

### Claim 9 (depends on 8)

Device according to claim 8, wherein the processing unit is configured to determine, per skin pixel or group of skin pixels, the ODIs from the data signals of the first and second data stream by
i) dividing, per skin pixel or group of skin pixels, the pulsatile components of the data signals of the first data stream by the pulsatile components of the data signals of the second data stream, or
ii) dividing, per skin pixel or group of skin pixels, the constant components of the data signals of the first data stream by the constant components of the data signals of the second data stream.

### Claim 10 (depends on 9)

Device according to claim 9, wherein the processing unit is further configured to determine, per skin pixel or group of skin pixels, the ODIs by selecting values of the pulsatile or constant components of the data signals of the first data stream at predetermined radial distances between the skin pixels or groups of skin pixels and illumination spots of the patterned illumination.

### Claim 11 (depends on 1)

System for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject, said system comprising:
a first illumination unit configured to emit a pattern of electromagnetic radiation to illuminate the skin region of the subject by a patterned illumination for radial imaging;
a second illumination unit configured to emit a homogenous illumination profile to illuminate the skin region of the subject homogenously for widefield imaging;
an imaging unit configured to detect the electromagnetic radiation transmitted through or reflected from the skin region of the subject and to derive data streams from the detected electromagnetic radiation; and
a device for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject according to claim 1 from the obtained data streams, wherein the device is configured to obtain a first data stream derived from a radial imaging of the skin region and a second data stream derived from a widefield imaging of the skin region, wherein both the first data stream and the second data stream are acquired at substantially the same wavelength.

### Claim 12

System for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject, said system comprising:
an illumination unit configured to emit a narrow radiation beam of electromagnetic radiation;
an optical diffuser configured to diffuse the electromagnetic radiation emitted by the illumination unit to illuminate the skin region of the subject homogenously and/or by a patterned illumination either by a patterned illumination for radial imaging or by a homogenous illumination for widefield imaging;
an imaging unit configured to detect the electromagnetic radiation transmitted through or reflected from the skin region of the subject and to derive data streams from the detected electromagnetic radiation; and
a device for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject according to any one of the preceding claims from the obtained data streams, wherein the device is configured to obtain a first data stream derived from a radial imaging of the skin region and a second data stream derived from a widefield imaging of the skin region, wherein both the first data stream and the second data stream are acquired at substantially the same wavelength.

### Claim 13 (depends on 12)

System according to claim 12,
wherein the imaging unit comprises an optical sensing array, in particular a two-dimensional image sensor, including a filter providing at least two different wavelength channels, and
the illumination unit is configured to emit electromagnetic radiation for illuminating the skin region of the subject with light in said at least two different wavelength channels.

### Claim 14

Method for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region of a subject, said method comprising the steps of:
obtaining data streams derived from detected electromagnetic radiation transmitted through or reflected from the skin region, said data streams comprising a data signal per skin pixel for a plurality of skin pixels of the skin region, wherein a first data stream is derived from radial imaging of the skin region and a second data stream is derived from widefield imaging of the skin region, wherein both the first data stream and the second data stream are acquired at substantially the same wavelength;
determining, per skin pixel or group of skin pixels, from the data signals of the first data stream and the second data stream, optical depth indices, ODIs, by dividing, per skin pixel or group of skin pixels, data signals of the first data stream by data signals of the second data stream, wherein the ODIs are indicative of the depth of the blood flow within the skin region at the skin pixels or groups of skin pixels;
creating an ODI image map of the skin region including the plurality of skin pixels from the determined ODIs;
creating an amplitude image map of the skin region including the plurality of skin pixels from amplitudes of the data signals of the second data stream; and
correcting the amplitude image map by correcting, per skin pixel or group of skin pixels, the amplitudes of the data signals of the second data stream by the determined ODIs.

### Claim 15 (depends on 14)

Computer program comprising program code means for causing a computer to carry out the steps of the method as claimed in claim 14 when said computer program is carried out on a computer.