# US 12,599,308 B2 · Sensor device, system, and method for performing an absolute blood pressure measurement

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- Number: US 12,599,308 B2
- Document ID: US12599308B2
- Status: Granted
- Kind: B2
- Application number: 18/256,162
- Filed: 2021-12-09
- Published: 2024-02-08
- Granted: 2026-04-14
- Earliest claimed: 2020-12-09
- Assignees: Ait Austrian Institute of Technology GmbH
- Applicants: Ait Austrian Institute of Technology GmbH
- Inventors: Siegfried Wassertheurer
- Web page: https://patentgrep.com/patent/US12599308B2

## CPC

- A61B 5/02125: {of pulse wave propagation time}
- A61B 5/0205: Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
- A61B 5/02225: {using the oscillometric method}
- A61B 5/0245: by using sensing means generating electric signals, {i.e. ECG signals}
- A61B 5/0295: using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
- A61B 5/053: Measuring electrical impedance or conductance of a portion of the body
- A61B 5/33: specially adapted for cooperation with other devices
- A61B 5/6843: {Monitoring or controlling sensor contact pressure}
- A61B 5/02141: {Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits (A61B5/02233, A61B5/0235 take precedence)}
- A61B 5/024: Measuring pulse rate or heart rate
- A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors
- A61B 2560/0238: Means for recording calibration data
- A61B 2560/0406: specially shaped apparatus housings
- A61B 2560/0468: Built-in electrodes
- A61B 2562/0247: Pressure sensors
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A sensor device or system for performing a blood pressure measurement comprises a finger abutment surface, a first sensor operative to sense blood volume pulses in a finger pressed on the finger abutment surface, a second sensor operative to sense a force or pressure with which the finger is pressed on the finger abutment surface, and processing circuitry operative to process amplitudes of the sensed blood volume pulses and the sensed force or pressure with which the finger is pressed on the finger abutment surface to determine an absolute blood pressure.

## Claims

### Claim 1

A sensor system for performing a blood pressure measurement, comprising:
a finger abutment surface;
a first sensor operative to sense blood volume pulses in a finger pressed on the finger abutment surface;
a second sensor operative to sense a force or pressure with which the finger is pressed on the finger abutment surface;
an electrocardiogram (ECG) sensor operative to sense ECG signals while the first sensor concurrently senses the blood volume pulses; and
processing circuitry operative to:
process amplitudes of the sensed blood volume pulses and the sensed force or pressure with which the finger is pressed on the finger abutment surface to determine an absolute blood pressure,
process an output of an ECG sensor and of the first sensor to determine pulse transit times (PTTs) of the blood volume pulses and to process the PTTs to determine a change in blood pressure, and
generate user instructions for adjusting the force or pressure based on the determined PTTs;
wherein the sensor system is configured to estimate at least one of a systolic blood pressure and a diastolic blood pressure and generate the user instructions that direct the user to change the pressure or force applied by the finger against the finger abutment surface based on the blood pressure estimate(s) obtained from the PTT-based blood pressure monitoring.

### Claim 2 (depends on 1)

The sensor system of claim 1, wherein the first sensor comprises a bioimpedance sensor.

### Claim 3 (depends on 2)

The sensor system of claim 2, wherein the bioimpedance sensor comprises an electrode on the finger abutment surface to be contacted by the finger pressed on the finger abutment surface and another electrode arranged transversely to and/or offset from the finger abutment surface to be contacted by another finger or by a hand holding the system.

### Claim 4 (depends on 1)

The sensor system of claim 1, wherein the processing circuitry is operative to execute a calibration routine for calibrating a PTT-based blood pressure monitoring process, the calibration routine using, as an input, the absolute blood pressure determined based on the amplitudes of the sensed blood volume pulses and the sensed force or pressure.

### Claim 5 (depends on 1)

The sensor system of claim 1, wherein the first sensor comprises at least one of: a photoplethysmography (PPG) sensor, a piezoelectric sensor, and/or a ballistographic sensor.

### Claim 6 (depends on 1)

The sensor system of claim 1, wherein the processing circuitry is operative to process the amplitudes of the sensed blood volume pulses and the sensed force or pressure to determine one or several of
a systolic blood pressure,
a diastolic blood pressure, and/or
a mean blood pressure that is a mean value of the systolic and diastolic blood pressures.

### Claim 7 (depends on 6)

The sensor system of claim 6, wherein the processing circuitry is operative to:
determine the systolic and/or diastolic blood pressure based on the force or pressure (pth,1) sensed by the second sensor in at least one pulse that is identified based on a threshold comparison of the amplitude of the blood volume pulses sensed by the first sensor, and/or
determine the diastolic blood pressure based on (i) a change in the amplitudes of the sensed blood volume pulses as a function of the sensed force or pressure or (ii) the systolic blood pressure and the mean blood pressure, and/or
determine the systolic blood pressure based on (i) a change in the amplitudes of the sensed blood volume pulses as a function of the sensed force or pressure or (ii) the diastolic blood pressure and the mean blood pressure.

### Claim 8 (depends on 6)

The sensor system of claim 6, wherein the processing circuitry is operative to:
determine N≥2 pairs of values each consisting of an amplitude height in the blood volume pulses and an associated pressure or force recorded while the pressure or force increases, and
apply a linear or non-linear regression to the pairs of values to determine a first sensor output at which the amplitude of the blood volume pulses reaches a first amplitude threshold (Ath,1) to determine the systolic blood pressure.

### Claim 9 (depends on 6)

The sensor system of claim 6, wherein the processing circuitry is operative to:
determine N≥2 pairs of values each consisting of an amplitude height in the blood volume pulses and an associated pressure or force recorded while the pressure or force decreases, and
apply a linear or non-linear regression to the pairs of values to determine a first sensor output at which the amplitude of the blood volume pulses reaches or falls below a second amplitude threshold (Ath,2), to determine the diastolic blood pressure.

### Claim 10 (depends on 1)

The sensor system of claim 1, further comprising a user interface operative to output:
user instructions to cause the user to change the force or pressure, and/or
information indicating the determined blood pressure.

### Claim 11 (depends on 1)

The sensor system of claim 1, wherein the sensor system is a cuffless system.

### Claim 12 (depends on 1)

The sensor system of claim 1, wherein the sensor system is operative to determine the absolute blood pressure without activation of an electromechanical actuator.

### Claim 13 (depends on 1)

The sensor system of claim 1, further comprising:
a communication interface for communicatively coupling the first and second sensors to at least part of the processing circuitry, and
a housing comprising the finger abutment surface, wherein the first sensor, the second sensor, and the communication interface are arranged in or on the housing.

### Claim 14 (depends on 13)

The sensor system of claim 13, wherein the housing comprises a depression in which the finger abutment surface is arranged.

### Claim 15

A method of performing a blood pressure measurement, comprising:
receiving a first sensor output representing sensed blood volume pulses in a finger pressed on a finger abutment surface;
receiving a second sensor output representing a sensed force or pressure with which the finger is pressed on the finger abutment surface;
receiving ECG signals sensed while the first sensor concurrently senses the blood volume pulses;
processing, by processing circuitry, amplitudes of the sensed blood volume pulses and the sensed force or pressure to determine an absolute blood pressure;
processing, by the processing circuitry, the ECG signals and the first sensor output to determine pulse transit times, PTTs, of the blood volume pulses;
processing, by the processing circuitry, the PTTs to determine a change in blood pressure; and
estimating at least one of a systolic blood pressure and a diastolic blood pressure;
generating, by the processing circuitry, user instructions that direct the user to change the pressure or force applied by the finger against the finger abutment surface based on the blood pressure estimate(s) obtained from the PTT-based blood pressure monitoring.

### Claim 16 (depends on 1, 15)

The method of claim 15, wherein the method is performed by the sensor system of claim 1.

### Claim 17 (depends on 6)

The sensor system of claim 6, wherein the processing circuitry is operative to:
determine the diastolic blood pressure based on (i) a change in the amplitudes of the sensed blood volume pulses as a function of the sensed force or pressure or (ii) the systolic blood pressure and the mean blood pressure, and
determine the systolic blood pressure based on (i) a change in the amplitudes of the sensed blood volume pulses as a function of the sensed force or pressure or (ii) the diastolic blood pressure and the mean blood pressure.
