# US 12,599,168 B2 · Cartridge comprising nicotine and a water-immiscible solvent > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,599,168 B2 - Document ID: US12599168B2 - Status: Granted - Kind: B2 - Application number: 17/621,325 - Filed: 2020-06-04 - Published: 2022-09-29 - Granted: 2026-04-14 - Earliest claimed: 2019-06-25 - Assignees: Philip Morris Products S.A. - Applicants: Philip Morris Products S.A. - Inventors: Jakub Bialek; Jean-Pierre Schaller; Aline Vuarnoz-Bize - Web page: https://patentgrep.com/patent/US12599168B2 ## CPC - A24F 40/10: Devices using liquid inhalable precursors - A61K 9/107: Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} - A24B 15/167: in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes - A24B 15/243: {Nicotine} - A24B 15/32: by acyclic compounds - A24F 40/30: Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges - A24F 40/42: Cartridges or containers for inhalable precursors - A61K 9/0009: {involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis} - A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid - A61K 31/465: Nicotine; Derivatives thereof - A24F: SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES (inhaling appliances for medical purposes, shaped like cigars, cigarettes or pipes A61M15/06) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A24B: MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF ## Abstract A cartridge for an aerosol-generating system is provided, the cartridge containing: a first liquid formulation including at least one of water and one or more water-miscible solvents; and a second liquid formulation including one or more water-immiscible solvents having a water solubility at 20° C. of less than or equal to about 100 mg/ml, in which at least one of the first liquid formulation and the second liquid formulation comprises nicotine. An aerosol-generating system is also provided, including the cartridge; and an aerosol-generating device including one or more atomizers configured to generate an aerosol from the first liquid formulation and the second liquid formulation contained in the cartridge. ## Claims ### Claim 1 A cartridge for an aerosol-generating system, the cartridge comprising: a first compartment containing a first liquid formulation comprising at least one of water and one or more water-miscible solvents; and a second compartment containing a second liquid formulation comprising one or more water-immiscible solvents having a water solubility at 20° C. of less than or equal to about 100 mg/ml, wherein the first liquid formulation and the second liquid formulation are distinct liquid formulations, wherein the first liquid formulation and the second liquid formulation are precluded from mixing in the cartridge prior to vaporization, and wherein at least one of the first liquid formulation and the second liquid formulation comprises nicotine. ### Claim 2 (depends on 1) The cartridge according to claim 1, wherein the first liquid formulation has a total water and water-miscible solvent content of greater than or equal to about 75 percent by weight. ### Claim 3 (depends on 1) The cartridge according to claim 1, wherein the first liquid formulation comprises water and one or more water-miscible solvents. ### Claim 4 (depends on 1) The cartridge according to claim 1, wherein the one or more water-miscible solvents are one or more water-miscible polyhydric alcohols selected from the group consisting of 1,3-butanediol, glycerine, propylene glycol, and triethylene glycol. ### Claim 5 (depends on 1) The cartridge according to claim 1, wherein the first liquid formulation comprises one or more water-soluble organic acids. ### Claim 6 (depends on 5) The cartridge according to claim 5, wherein the one or more water-soluble organic acids are selected from the group consisting of acetic acid, lactic acid, levulinic acid, and pyruvic acid. ### Claim 7 (depends on 5) The cartridge according to claim 5, wherein the first liquid formulation has a water-soluble organic acid content of greater than or equal to about 2 percent by weight. ### Claim 8 (depends on 1) The cartridge according to claim 1, wherein the second liquid formulation has a water-immiscible solvent content of greater than or equal to about 70 percent by weight. ### Claim 9 (depends on 1) The cartridge according to claim 1, wherein the one or more water-immiscible solvents are selected from the group consisting of polysorbate 80, triacetin, triethyl citrate, oleic acid, and a mixture of decanoyl- and octanoyl glycerides. ### Claim 10 (depends on 1) The cartridge according to claim 1, wherein the one or more water-immiscible solvents comprise one or more partially water-soluble solvents having a water solubility at 20° C. of between about 20 mg/ml and about 100 mg/ml. ### Claim 11 (depends on 1) The cartridge according to claim 1, wherein the one or more water-immiscible solvents comprise one or more water-insoluble solvents having a water solubility at 20° C. of less than or equal to about 5 mg/ml. ### Claim 12 (depends on 1) The cartridge according to claim 1, wherein the second liquid formulation comprises one or more flavourants. ### Claim 13 (depends on 1) The cartridge according to claim 1, wherein a ratio of a weight percent first liquid formulation content to a weight percent second liquid formulation content of the cartridge is greater than or equal to about 2. ### Claim 14 (depends on 1) The cartridge according to claim 1, further comprising one or more atomizers configured to generate an aerosol from the first liquid formulation and the second liquid formulation. ### Claim 15 (depends on 1) An aerosol-generating system, comprising: a cartridge according to claim 1; and an aerosol-generating device comprising one or more atomizers configured to generate an aerosol from the first liquid formulation and the second liquid formulation contained in the cartridge.