Health analysis based on ingestible sensors

A computer-implemented method, comprising:

• receiving, by a computer system, an indicator collected by a first sensor, wherein:
• the indicator identifies a first adherence event at a first indicator time indicating at least a first medication was ingested by a patient;
• the first medication is associated with an ingestible transmitter;
• and
• the ingestible transmitter, responsive to exposure to stomach acid of the patient, automatically switches from a deactivated state into a transmitting state and transmits the indicator;
• obtaining physiological data of the patient collected by a second sensor, the physiological data including first physiological data collected after the indicator and second physiological data collected prior to the indicator;
• determining, by the computer system, a history of medication ingested by the patient based on receipt of indicators associated with one or more adherence events including the first adherence event, wherein the history of medication ingested by the patient indicates whether first medication was taken as prescribed or whether one or more doses were missed;
• determining, by the computer system, a medication administration history of the physiological data of the patient based on the history of the medication ingested by the patient, the first physiological data, and the second physiological data;
• and
• predicting, by the computer system and based on a comparison of the medication administration history of the physiological data of the patient to peer group data, a an out-of-range efficacy, wherein the out-of-range efficacy includes a degree to which the first medication effects a physiological response of the patient, when taken as prescribed, that is outside of a normal range.