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US 12,597,493 B2Granted
Workflows for preparing and analyzing clinical samples
AssigneeWaters Technologies Corporation
InventorsThomas S. McDonald, Kevin Wyndham, Johannes Vissers, Edouard S. P. Bouvier
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Abstract
The present disclosure relates to methods and workflows for processing and analyzing clinical samples (e.g., nasal swabs, throat swabs, plasma samples, urine, etc.) In general, the methods and workflows involve the detection of an infectious state and are improved over contemporary methods due to increased throughput with improved resolution of positive results.
Claims12
A method for preparing biological samples collected from different mammalian subjects for clinical diagnosis via mass spectrometry, the method comprising:
- pooling two or more biological samples;
- digesting the pooled two or more biological samples;
- enriching the pooled two or more biological samples, wherein enriching comprises contacting the samples with an antibody-based affinity ligand immobilized on a substrate, followed by washing and elution to form an eluate;
- and
- analyzing the eluate with mass spectrometry for clinical diagnosis.
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Dependencies are inferred from the claim text.