# US 12,595,515 B2 · Prognosis method of cancer

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- Number: US 12,595,515 B2
- Document ID: US12595515B2
- Status: Granted
- Kind: B2
- Application number: 17/599,330
- Filed: 2020-03-27
- Published: 2022-06-16
- Granted: 2026-04-07
- Earliest claimed: 2019-03-29
- Assignees: Centre National De La Recherche Scientifique; Centre Leon Berard; Institut National de la Sante et de la Recherche Medicale; Universite Claude Bernard Lyon 1
- Applicants: Centre National De La Recherche Scientifique; Centre LéOn BéRard; Institut National De La Santé Et De La Recherche MéDicale; Université Claude Bernard Lyon 1
- Inventors: Véronique Maguer-Satta; Boris Guyot; Flora Clément; Pierre Saintigny; Jean-Philippe Foy; Emmanuel Delay
- Web page: https://patentgrep.com/patent/US12595515B2

## CPC

- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- C12Q 2600/118: Prognosis of disease development
- C12Q 2600/158: Expression markers
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

A method of prognosis of patient outcome and of the resistance to a chemotherapy treatment of an individual afflicted by a tumor. The method involves determining the amount of the product of each of at least 21 genes belonging to the group of 160 genes as set forth in SEQ ID NO: 1 to SEQ ID NO: 160.

## Claims

### Claim 1

A composition consisting of pairs of oligonucleotides allowing the detection of at least 21 genes belonging to the group of 160 genes as set forth in SEQ ID NO: 1 to SEQ ID NO: 160, said at least 21 genes being the genes of the group consisting of the genes as set forth in SEQ ID NO: 7, SEQ ID NO: 11, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 34, SEQ ID NO: 40, SEQ ID NO: 54, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 100, SEQ ID NO: 102, SEQ ID NO: 127, SEQ ID NO: 141, SEQ ID NO: 149, SEQ ID NO: 150 and SEQ ID NO: 160,
wherein the pairs of oligonucleotides are attached to a microarray.