Linkage modified oligomeric compounds and uses thereof

An oligomeric compound comprising a modified oligonucleotide consisting of 12-30 linked nucleosides linked through internucleoside linking groups, wherein:

• at least one nucleoside comprises a modified sugar moiety;
• the modified oligonucleotide comprises a deoxy region consisting of 6-11 linked nucleosides wherein each nucleoside of the deoxy region is a stereo-standard DNA nucleoside;
• and
• at least one of the internucleoside linking groups of the modified oligonucleotide has Formula XVII:
• wherein independently for each internucleoside linking group having Formula XVII:
• X is selected from O or S;
• R1 is selected from H, C1-C6 alkyl, and substituted C1-C6 alkyl;
• and
• T is SO2R2, wherein R2 is selected from a heterocycle, a substituted heterocycle, an aromatic heterocycle, a substituted aromatic heterocycle, a diazole, a substituted diazole, a C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, substituted C1-C6 alkyl, substituted C1-C6 alkenyl substituted C1-C6 alkynyl, and a conjugate group.