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US 12,595,461 B2Granted
Microorganism of Corynebacterium genus having enhanced L-arginine or L-citrulline productivity and a method for producing L-arginine or L-citrulline using the same
AssigneeDaesang Corporation
InventorsMi Ryu, Sun Jun Yoon, In Pyo Hong, Seok Hyun Park
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Abstract
The present disclosure relates to a Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity and a method of producing L-arginine or L-citrulline using the same. The Corynebacterium sp. mutant strain has enhanced activity of acetylglutamate kinase involved in the L-arginine biosynthesis pathway, and thus is capable of producing L-arginine or L-citrulline in an increased yield compared to a parent strain.
Claims3
A Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity by having enhanced activity of acetylglutamate kinase,
- wherein said acetylglutamate kinase of the Corynebacterium sp. mutant strain having increased L-citrulline productivity has a substitution of aspartic acid for histidine at amino acid position 245 in the amino acid sequence of SEQ ID NO:
- 2,
- wherein said acetylglutamate kinase of the Corynebacterium sp. mutant strain having increased L-arginine productivity has a substitution of leucine for glutamic acid at amino acid position 258 or a substitution of aspartic acid for histidine at amino acid position 245 in the amino acid sequence of SEQ ID NO:
- 2.
1 more element
Dependencies are inferred from the claim text.