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US 12,595,299 B2Granted
FC variants
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Tatsuhiko Tachibana, Yuki Iwayanagi
Life of this patent
Estimating the term…
Abstract
One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.
Claims17
A human Fc region variant comprising
- a heavy chain constant region that comprises SEQ ID NO:18 with only amino acid substitutions selected from:
- (a) N434A/Q438R/S440E in the EU numbering system;
- (b) N434A/Y436T/Q438R/S440E in the EU numbering system;
- (c) N434A/Y436V/Q438R/S440E in the EU numbering system;
- (d) M428L/N434A/Q438R/S440E in the EU numbering system;
- (e) M428L/N434A/Y436T/Q438R/S440E in the EU numbering system;
- and
- (f) M428L/N434A/Y436V/Q438R/S440E in the EU numbering system;
- or
- a heavy chain constant region that comprises SEQ ID NO:21 with only amino acid substitutions selected from:
- (g) N434A/Q438R/S440E in the EU numbering system;
- (h) N434A/Y436T/Q438R/S440E in the EU numbering system;
- (i) N434A/Y436V/Q438R/S440E in the EU numbering system;
- (j) M428L/N434A/Q438R/S440E in the EU numbering system;
- (k) M428L/N434A/Y436T/Q438R/S440E in the EU numbering system;
- and
- (l) M428L/N434A/Y436V/Q438R/S440E in the EU numbering system.
14 more elements
Dependencies are inferred from the claim text.