Anti-NGF antibody and antigen-binding fragment thereof, preparation method, and application thereof
AssigneeXiyuan Anjian Medicine (Shanghai) Co., Ltd
InventorsXiaohui Yuan, Guoyong Wang, Yujiao Liu, Donghong Zheng
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Abstract
Provided are an anti-NGF antibody or an antigen-binding fragment thereof, a preparation method and an application thereof. Also provided is an isolated polynucleotide encoding the anti-NGF antibody or the antigen-binding fragment thereof, as well as a vector containing the isolated polynucleotide. Also provided is use of the antibody or the antigen-binding fragment thereof of the present invention in preparing the medicament for the treatment of NGF-mediated diseases or disorders.
Claims6
An antibody or antigen-binding fragment thereof capable of specifically binding to nerve growth factor (NGF), wherein,
- the antibody or antigen-binding fragment thereof comprises:
- VH having the sequence as set forth in SEQ ID NO:
- 9 and VL having the sequence as set forth in SEQ ID NO:
- 11;
- the VH comprises:
- VH CDR1 as set forth in SEQ ID NO:
- 19, VH CDR2 as set forth in SEQ ID NO:
- 20 and VH CDR3 as set forth in SEQ ID NO:
- 21, and the VL comprises:
- VL CDR1 as set forth in SEQ ID NO:
- 28, VL CDR2 as set forth in SEQ ID NO:
- 29, and VL CDR3 as set forth in SEQ ID NO:
- 30.
Dependencies are inferred from the claim text.